Increasing evidence shows that structural variants represent an overlooked aspect of genetic variation with consequential evolutionary roles. Among those, copy number (CNVs), including duplicated genomic regions and transposable elements (TEs), may contribute to local adaptation and/or reproductive isolation among divergent populations. Those mechanisms suppose CNVs could be used infer neutral ...

In the framework of Thomas-Fermi approximation, we study systematically EOSs and microscopic structures neutron star matter in a vast density range with $n_\mathrm{b}\approx 10^{-10}$-2 $\mathrm{fm}^{-3}$, where various covariant functionals are adopted, i.e., those nonlinear self couplings (NL3, PK1, TM1, GM1, MTVTC) density-dependent (DD-LZ1, DDME-X, PKDD, DD-ME2, DD2, TW99). It is found that...

For potential clinical extrapolation of in vitro findings, it is of interest to relate the measured effect of an anticancer agent to concentration and exposure time. The Hill model (A. V. Hill, J. Physiol., 40: iv-vii, 1910) is commonly used to describe pharmacodynamic (PD) effects, including drug-induced growth inhibition of cancer cells in vitro. The IC(X)n x T = k relationship, in which IC(X...

INTRODUCTION Nocturnal enuresis is involuntary urination while sleeping after a certain age, usually five years, when children should have established bladder control. The prevalence has been found to be up to 20% in five year old children, and it is considered the most common urological childhood complication. MATERIAL AND METHODS This study was conducted on Makassed School children aged 5-1...

Population genetics studies of allopolyploid species lag behind those of diploid species because of practical difficulties in analysis of homeologs-duplicated gene copies originating from hybridized parental species. Pool-Seq, i.e. massive parallel sequencing of pooled individuals, has high potential for detecting nucleotide polymorphisms within and among multiple populations; however, its use ...

The neutron skin thickness ?rnp of heavy nuclei is essentially determined by the symmetry energy density slope L(?) at ?c=0.11fm?3?2/3?0 (?0 nuclear saturation density), roughly corresponding to average finite nuclei. PREX collaboration recently reported a model-independent extraction ?rnp208=0.283±0.071 fm for Pb208, suggesting rather stiff Esym(?) with L(?c)?52 MeV. We show that cannot be too...

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Abstract We introduce a family of equations state (EoS) for hybrid neutron star (NS) matter that is obtained by two-zone parabolic interpolation between soft hadronic EoS at low densities and set stiff quark high within finite region chemical potentials $$\mu _H&lt; \mu &lt; _Q$$ ? H</mml:mi...

Abstract We introduce a new nonparametric representation of the neutron star (NS) equation state (EOS) by using variational autoencoder (VAE). As deep neural network, VAE is frequently used for dimensionality reduction since it can compress input data to low-dimensional latent space encoder component and then reconstruct decoder component. Once trained, one take as generator. employ 100,000 EOS...