Introduction: Gastroenteropancreatic neuroendocrine tumours (GEP NETs) are a heterogenous group of tumours of various clinical presentations. Proliferative activity of tumour cells is an essential parameter determining the course of the disease and affecting the prognosis. The Ki-67 antigen is an important marker of cell proliferation, which shows activity in all the phases of the cell cycle, e...

Rossella Melchiotti ([email protected]) Kia Joo Puan ([email protected]) Anand Kumar Andiappan ([email protected]) Tuang Yeow Poh ([email protected]) Mireille Starke ([email protected]) Lydia Li Zhuang ([email protected]) Kerstin Petsch ([email protected]) Adrian Tuck Siong Lai ...

We herein report a 59-year-old male patient with a recurrent carcinoid tumor of the middle ear 7 years after a tympanomastoidectomy. The CT and dynamic MRI demonstrated an extensive tumor close to the carotid artery canal and the jugular bulb, and the tumor was removed by a partial petrosectomy with a transmastoid approach. The histopathological findings revealed a solid and trabecular tumor wi...

Cell kinetic parameters were measured in four cases of meningioma showing regrowth. The cell cycle time (Tc) and tumor doubling time (Td) were established by histological evaluation of the biopsy specimens and calculation of the growth curve based on computed tomography (CT)/magnetic resonance (MR) images. MIB-1 mouse monoclonal antibody, which recognizes an epitope of the Ki-67 antigen, was us...

In today’s information society, computer-supported collaborative learning (CSCL) has become increasingly important. However, there are still problems regarding CSCL, especially interaction problems within groups. This study is an investigation of whether a specific kind of awareness tool, namely a tool for making the collaborators aware of relevant domain knowledge and the information underlyin...

There is evidence to suggest that the gas-water interface serves as an important retention domain for volatile organic compounds (VOCs) in vadose-zone soil. Moreover, vapor adsorption at the gas-water interface may represent the dominant retention mechanism under certain conditions. In general, vapor-phase interfacial adsorption is most significant for low organic matter soils at intermediate w...

Pituitary adenomas (PAs) show a broad clinicomorphological spectrum. The proliferation activity, evaluated by MIB-1 labelling index (LI), and p53 expression have been pointed as predictive markers for invasiveness and progression. The aim of this study was to evaluate the proliferation rate and p53 expression and to look for any relationships with the clinical behaviour and follow-up results in...

Our study aimed at examining significance of metallothionein (MT) expression in ductal breast cancers by determination of a relationship between expression of MT protein (MT-1/2) and selected prognostic factors, including grade of histological differentiation (G), expression of Ki-67 proliferative antigen, expression of estrogen receptors (ER) and progesterone receptors (PgR) and expression of ...

The study aimed at examining a relationship between expression of Ki-67 antigen and minichromosome maintenance 2 protein (MCM-2) and a grade of histological malignancy G in ductal breast cancers. The function of widely used marker of proliferation Ki-67 is still not clear. In contrast, the MCM-2 protein is well known to play an important role in controlling the cell cycle. Both proteins represe...