AIM The purpose of this study was to investigate the possible influence of age and gender on association between -765G > C COX-2 genetic polymorphism and gastric adenocarcinoma risk in Iranian patients. BACKGROUND The promoter polymorphism of COX-2 gene -765G > C has been described to play an important role in many cancers such as gastric cancer. PATIENTS AND METHODS We carried out single-n...

Host genetic factors may play a key role in determining the long-term outcome of the Helicobacter pylori (H. pylori) infection. Toll-like receptor 4 (TLR4) mediated recognition of lipo-polysaccharide (LPS) is required for efficient recognition of gram-negative bacterial infections. The aim of this study is to investigate the effects of common polymorphisms of TLR4 Asp299Gly, Thr399Ile in patien...

Objective. To evaluate the association of -174G/C IL-6 polymorphism with failure in therapeutic response to methotrexate (MTX) or leflunomide (LEF). This prospective, observational cohort included 96 Mexican-Mestizo patients with moderate or severe rheumatoid arthritis (RA), initiating MTX or LEF, genotyped for IL-6 -174G/C polymorphism by PCR-RFLP. Therapeutic response was strictly defined: on...

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 aim : this study aimed to determine the association between pd-1.5c/t (rs2227981, +7785) and the risk of gastric cancer (gc) in an iranian population. background : gastric cancer is the fourth most common cancer in the world. the programmed death 1 (pd-1) is a member of the cd28 super family. pd-1 is a negative regulator of t...

We synthesize hexagonal shaped single-crystal graphene, with edges parallel to the zig-zag orientations, by ambient pressure CVD on polycrystalline Cu foils. We measure the electronic properties of such grains as well as of individual graphene grain boundaries, formed when two grains merged during the growth. The grain boundaries are visualized using Raman mapping of the D band intensity, and w...

FLOYD MERRELL (b. 16 November 1937). Academic Status: Professor of Spanish and Latin American Studies. Mail Address: Dept. of Foreign Languages and Literatures, Purdue University, West lafayette, IN 47907, USA. E-mail: . Personal Office Tel: (765) 496-2265. Fax: (765) 496-1700. Educational Background: Ph.D., University of New Mexico, 1972. Research Interests: (1) Spanish an...

P<P Published online July 18, 2013 in advance of the print journal. Preprint Accepted likely to differ from the final, published version. Peer-reviewed and accepted for publication but not copyedited or typeset; preprint is License Commons Creative . http://creativecommons.org/licenses/by-nc/3.0/ described at a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as ). After six m...

BACKGROUND TP53 mutations are the most common genetic alterations in human cancers. There are also several polymorphisms in both exons and introns of TP53 that may influence its anti-tumor functions and increase the risk of cancer development. Associations of the TP53 intron 6 G13964C polymorphism with increased risk of development of several cancers have been investigated in numerous studies, ...