Botulinum neurotoxins (BoNTs), which have been exploited as cosmetics and muscle-disorder treatment medicines for decades, are well known for their extreme neurotoxicity to humans. They pose a potential bioterrorism threat because they cause botulism, a flaccid muscular paralysis-associated disease that requires immediate antitoxin treatment and intensive care over a long period of time. In add...

The effectiveness of cell-mediated immunotherapy for cancer can be limited by loss-of-antigen mutations that occur during tumor growth. In neuroblastoma, amplification of the MYCN oncogene correlates with rapid tumor progression and a poor prognosis overall. We propose that the MYCN protein, the high-level expression of which is required for maintenance of the malignant phenotype, would be an i...

Let A be a factor von Neumann algebra and ? preserve n-tuple new product derivations on A, that is, for every A1,A2,... ,An ?(A1 A2 ?...? An) = ?(A1) An + A1 ?(A2) ?... ... ?(An) where Ai ?Aj A*iAj ?A*jAi i,j N, then is additive *-derivation, the condition ?(?I/2) self-adjoint operator {1,i}.

ABH antigens are present on platelets from individuals of the corresponding red cell phenotype, but the extent to which these antigens are intrinsic or adsorbed remains undefined. To evaluate platelets for intrinsic H substance, an IgM mouse monoclonal antibody against type 2H chain (the intrinsic H structure found on erythrocytes) was labeled with 125I and incubated with platelets from donors ...

Antibodies are highly specific for their target molecules, but their poor brain penetrance has restricted their use as PET ligands for imaging of targets within the CNS. The aim of this study was to develop an antibody-based radioligand, using the TribodyTM format, for PET imaging of soluble amyloid-beta (Aβ) protofibrils, which are suggested to cause neurodegeneration in Alzheimer's disease. A...

Let a1,a2,…,ak be positive integers with gcd(a1,a2,…,ak)=1. Frobenius number is the largest integer that NOT representable in terms of a1,a2,…,ak. When k?3, there no explicit formula general, but some formulae may exist for special sequences a1,a2,…,ak, including, those forming arithmetic progressions and their modifications. In this paper, we give power weighted sum nonrepresentable integers. ...

The HLA-A2-specific mouse monoclonal antibody BB7.2 plus complement has been used to immunoselect variant clones of the lymphoblastoid cell line T5-1 (HLA-A1, -A2, -B8, and -B27). Members of one class of variant clones appear to express cell surface HLA-A2 molecules that display reduced reactivity with the selecting antibody, but normal or near normal reactivities with some other HLA-A2-specifi...