The aim of this study was to evaluate the effect of different capsule filling manufacturing techniques and storage conditions on the release of the active ingredients from herbal capsules during the dissolution test in vitro. Different techniques for the preparation of the original mixture of dry extracts were applied, and subsequently capsules with six different fillings were prepared. The sta...

The microcapsules in drug delivery systems can prevent degradation of drugs and help to control the release rate. To enhance the targeted delivery effect of the microcapsules to cancer cells, some specific ligands such as folic acid (FA) are necessarily further conjugated. Herein, covalent poly(allylamine hydrochloride) (PAH) multilayers were fabricated on CaCO3 microparticles under the cross-l...

The ability of the egg capsules of three intertidal gastropod species to protect embryos against low-salinity stress was examined. Encapsulated embryos of Ilyanassa obsoleta (Say), Nucella lamellosa (Gmelin), and N. lima (Gmelin) were far more tolerant of transfer to water of reduced salinity than were embryos which had been prematurely removed from egg capsules and transferred to low-salinity ...

A standard acid resistant microsphere pancreatic enzyme preparation was compared with identical capsules half filled with mini-tablets of a new high lipase preparation in a randomised double blind crossover study in children with cystic fibrosis. Each patient received his/her usual number of capsules and the same dose of lipase during each period of the study. Eighteen patients completed the st...

Calculi for propositional dynamic logics have been investigated since the introduction of this logic in the late seventies. Only in recent years have practical procedures been suggested and implemented. In this paper, we compare three such systems, namely, the Tableau Workbench by Abate, Goré, and Widmann (2009), the pdlProver system by Goré and Widmann (2009), and the MLSolver system by Friedm...

Active brain stimulation to abate epileptic seizures has shown mixed success. In spike-wave (SW) seizures, where the seizure and background state were proposed to coexist, single-pulse stimulations have been suggested to be able to terminate the seizure prematurely. However, several factors can impact success in such a bistable setting. The factors contributing to this have not been fully inves...