CONTEXT Levothyroxine monotherapy is the treatment of choice for hypothyroid patients because peripheral T4 to T3 conversion is believed to account for the overall tissue requirement for thyroid hormones. However, there are indirect evidences that this may not be the case in all patients. OBJECTIVE To evaluate in a large series of athyreotic patients whether levothyroxine monotherapy can norm...

The aim of the present study was to establish the usefulness of conventional thyroid ultrasonography (US) and color flow-doppler (CFD) sonography in the assessment of 'cold' thyroid nodules. One hundred and four consecutive patients with thyroid nodules who were to undergo surgery were examined by US and CFD before thyroidectomy. Conventional US evaluated the presence of a halo sign, hypoechoge...

Although partial thyroidectomy has lower operative risk, it potentially caries the risk of leaving residual malignancy. The aim of this study was to establish malignancy rate in residual thyroid tissue in patients with differentiated thyroid cancer (DTC) who underwent partial thyroid surgery and subsequently had completion thyroidectomy. We also investigated a number of clinical and biochemical...

Liver Transplantation Experimental Beginnings Clinical Trials of Orthotopic Transplantation Indications for Orthotopic TransplantatIon TIssue Matching The Donor Operation The RecipIent Operation PostoperatIve Care Immunosuppression Rejection Under Immunosuppression Survival Aller Liver Replacement Causes of Mortality Steps to Reduce Mortality Opt/on of Auxiliary Liver Transplantation Potential ...

OBJECTIVE To investigate the molecular mechanisms underlying the influence of alteration of iodine trapping on the prognosis of metastatic papillary thyroid carcinomas, focusing on the expression of the Na+/I(-) symporter (NIS). DESIGN We evaluated the expression of the NIS gene in a series of 11 enlarged neck lymph-node metastases of papillary thyroid carcinomas, including four patients in w...

BACKGROUND Transplantation of ovarian tissue is, at present, the only clinical option available to restore fertility using cryopreserved ovarian tissue. More than 30 transplantations of cryopreserved tissue have been reported, and six babies have been born, worldwide, following this procedure. Despite these encouraging results, it is essential to optimize the procedure by improving the follicul...

Photoperiod and temperature are well-established environmental cues for gonadal growth in seasonally reproducing organisms. The photoperiod is known to regulate seasonal reproduction via induction of thyroid hormone regulating genes the saccus vasculosus (SV) fishes. However, SV absent many breeding fishes, including Heteropneustes fossilis. H. fossilis a long-day catfish which recrudescence be...

OBJECTIVE Ectopic thyroid gland is a rare occurrence with a prevalence of 1 per 100,000 to 300,000 people. Hashimoto's thyroiditis involving ectopic thyroid tissue is particularly unusual. We describe the presentation, workup, surgical management, and brief review of the literature. METHODS Retroactive review of an 83-year-old white female patient record. As a case report, this project was ex...

Abstract Data indicate that ultrahigh dose rate (>106 Gy/second) FLASH radiotherapy (FLASH-RT) delivery of radiation reduces normal tissue damage without compromising tumor response. Orthotopic glioblastoma mouse studies now demonstrate fraction size, total dose, and number fractions are critical parameters for FLASH-RT cognitive sparing See related article by Montay-Gruel et al., p. 775

Ectopic thyroid tissue refers to presence of thyroid tissue at locations away from the normal site in the pretracheal region in the lower neck. Few of such cases are associated with a functioning thyroid gland in its normal anatomical location. However in many cases, the ectopic thyroid gland is the only functioning thyroid. Radionuclide scan is mandatory when dealing with an ectopic thyroid le...