Non-steroidal Anti-inflammatory drugs (Aceclofenac, Mefenamic acid) have conjugated with different antioxidants such as Thymol, Menthol which having antiulcerogenic activity with the NSAIDsantioxidant mutual prodrug gastro sparing NSAIDs devoid of Ulcerogenic side effects. Two mutual Prodrugs have synthesized in which NSAIDs have been conjugated with different antioxidants by a glycolic acid sp...

A series of some novel diarylsulfonylurea-chalcone hybrids synthesized in our earlier study as potential 5lipoxygenase inhibitors were now subjected for the anti-inflammatory activity by using carrageenan induced rat paw edema method. The compounds 4o, 4q, 4r, 4t and 4y were selected for the study; the rationale behind the selection of these compounds is mainly due to their potential inhibitory...

Colchicine is used mainly for the treatment of gout and familial mediterranean fever. The use of colchicine is limited by its toxicity, and colchicine overdose is associated with a high mortality rate. Herein, we are reporting a young man who presented to the emergency department after ingesting 13.5 mg of colchicine and 1200 mg of aceclofenac (non-steroid anti-inflammatory drug) for deliberate...