Traditionally, the ketone body β-hydroxybutyrate (βOHB) has been looked upon as a carrier of energy from liver to peripheral tissues during fasting or exercise. However, βOHB also signals via extracellular receptors and acts as an endogenous inhibitor of histone deacetylases (HDACs). These recent findings support a model in which βOHB functions to link the environment, in this case the diet, an...

2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic potential for the treatment of various diseases, including several lysosomal storage disorders. A stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc), the iminosugar analog of N-acetylglucosamine, with a high overall yield is here described. This nov...

The study reports the convenient and efficient synthesis of several new analogues of 3β-substituted amides of 17a-aza-Dhomo-4-androsten-17-one (11a-11d) from commercially available Diosgenin as the starting material. The structures of newly synthesized compounds were confirmed by IR, H NMR, C NMR and mass spectrometry. We herein report the 5α-reductase inhibitory, antimicrobial and antioxidant ...

The metabolism of FFA and ketone bodies was studied in fasted rats by infusing at a constant rate tracer amounts of FFA-(3)H, beta-hydroxybutyrate-(14)C or acetoacetate-(14)C for periods up to 2 hr. Blood that was removed for analyses was replaced by continuous transfusion. The rates of turnover of FFA, beta-hydroxybutyrate, and acetoacetate in rats fasted for 2 days were, respectively, 3.2, 5....

In the title mol-ecule, C(11)H(14)N(2)O(3), an intra-molecular O-H⋯O hydrogen bond closes an almost planar [maximum deviation = 0.022 (13) Å] six-membered ring and enforces the cis conformation of the keto group with respect to the hy-droxy substituent. In the crystal, inter-molecular N-H⋯O hydrogen bonds link the moleclues into ribbons extended along [10]. Weak inter-molecular C-H⋯O inter-acti...

The title compound, C(13)H(17)NO(5)S, is approximately planar (r.m.s. deviation for the non-H atoms = 0.055 Å). Its conformation is stabilized by N-H⋯O and C-H⋯O hydrogen bonds, which both generate S(6) rings. The crystal packing only features van der Waals contacts.