The purpose of this study was to determine whether cyclic guanosine monophosphate inhibits contraction through inhibition of phosphatidylinositol hydrolysis. Sodium nitroprusside and atriopeptin II, agents which activate soluble and particulate guanylate cyclase, respectively, inhibited norepinephrine-induced contraction and accumulation of inositol monophosphate, a measure of phosphatidylinosi...

Introduction: Nitric Oxide is an important endogenous compound that acts as bronchodilator in trachea. Electromagnetic fields (EMF) affect nitric oxide level in different tissues. The interaction of nitrergic and cholinergic systems in airways has been reported. Therefore, the present study was performed to evaluate the interaction of cholinergic and nitrergic systems in the trachea of rats ...

objective(s) achillea genius is widely used in traditional medicine for gastrointestinal disorders. the aim of this study was to investigate the effects of aqueous-ethanol extract of achillea wilhelmsii on rat’s gastric motility in basal and vagal stimulated conditions. materials and methods twenty four wistar rats were randomly divided into two groups: control and test. the extract was prepare...

Differences in the release and content of acetylcholine and the alpha 2 adrenoceptor mediated interaction between noradrenergic and cholinergic neurons were investigated by neurochemical and pharmacological methods in aganglionic and ganglionic segments of isolated human colon taken from children suffering from Hirschsprung's disease. Both at rest and during transmural stimulation the release o...

Objective: Bladder function depends upon several complex signaling pathways that induce either contraction or relaxation. We performed nerve re-routing surgery on bladder of decentralized dogs (reinnervated) as a model with the goal of restoring bladder function in spinal cord injured patients. The neuromuscular nicotinic receptor blocker, succinylcholine blocks spinal root-stimulated bladder c...

Myasthenia gravis is a chronic disease characterized by abnormal fatigue of the voluntary muscles. This fatigue is due to a progressive failure of conduction at the myoneural junction after muscle contraction, and can be temporarily relieved by prostigmine sulphate (Walker, 1934). The exact nature of the neuromuscular block remains obscure, and an analysis of neuromuscular transmission in myast...

Several reports have shown the various effects of grape (Vitis vinifera) seed extract such as antioxidant, hypotensive, hypolipidemic and vasodilatory effects. The aim of present study was to investigate the effect of grape leaf hydroalcoholic extract on isolated rat tracheal contractions induced by KCl and acetylcholine. The trachea was removed from male adult Sprague-Dawley rat and placed in ...

Background: Teucrium polium has been known as an important traditional medicinal plant and is used for different therapeutic purposes such as gastrointestinal disorders. Therefore, the anti-spasmodic and antinociceptive activities of aqueous extract of Teucrium polium w as examined. Methods: Anti-spasmodic effect of different concentrations (47-470 mg/l) of Teucrium polium extract was assessed ...

Abstract
 Objective: This study aimed to investigate the antioxidant effects of folic acid and its on contraction relaxation responses in rat aorta hyperhomocysteinemic rats.
 Methods: Thirty-four male Wistar Albino rats were allocated into four groups. Rats hyperhomocysteinemia group (Group 1, n=9) received 1g/kg/day methionine via orogastric gavage for 30 days then injected with int...

Objective(s) Achillea genius is widely used in traditional medicine for gastrointestinal disorders. The aim of this study was to investigate the effects of aqueous-ethanol extract of Achillea wilhelmsii on rat’s gastric motility in basal and vagal stimulated conditions. Materials and Methods Twenty four Wistar rats were randomly divided into two groups: control and test. The extract was prep...