BACKGROUND Circumscribed acral hypokeratosis (CAH) is an idiopathic condition that typically presents as an acquired, solitary, asymptomatic, well-defined, depressed, flat-based deformity, with a slightly raised border on the palm or, rarely, the sole. Histologically, the lesional epidermis is depressed with a characteristic, abrupt, hyperkeratotic, slightly-raised ridge at the transition from ...

Sir, Chemotherapy-induced acral erythema (CIAE) is a cytotoxic drug reaction to certain systemic chemotherapeutic agents, such as £uorouracil, doxorubicin, and especially cytosine arabinoside (1). Following discontinuation of chemotherapy, cutaneous lesions subside in 1 ^ 2 weeks with eventual desquamation. Rechallenge of patients with similar chemotherapeutic agents has reproduced the reaction...

Acral melanoma commonly occurs in areas that are not exposed to much sunlight, such as the sole of foot. Little is known about risk factors and mutational processes plantar acral melanoma. Nuclear envelope rupture during interphase contributes genome instability cancer. Here, we show nuclear micronuclear membranes cells frequently ruptured by macroscopic mechanical stress on surface due weight-...

Epidermoid cysts are benign subcutaneous lesions commonly seen in hairy regions of the body but very rare occurrence acral palm-plantar due to lack sebaceous glands.