Peng, Y. B., Matthias Ringkamp, James N. Campbell, and Richard A. Meyer. Electrophysiological assessment of the cutaneous arborization of Ad-fiber nociceptors. J. Neurophysiol. 82: 1164–1177, 1999. Little is known about the relationship between the branching structure and function of physiologically identified cutaneous nociceptor terminals. The axonal arborization itself, however, has an impac...

Isolated single (Xenopus) muscle fibers were stained with a non-permeant potential-probing dye, merocyanine rhodanine (WW375) or merocyanine oxazolone (NK2367). When the fiber was massively stimulated, an absorption change (wave a), which seemed to reflect the action potential, occurred. Simultaneous recording of optical changes and intracellular action potentials revealed that the time-course ...

The influence of activation sequences on action potential configuration, especially in the repolarization phase, was examined in isolated canine ventricular muscles. Action potentials were recorded from the epicardial surface in the center of a preparation having nearly uniform fiber orientation (25 x 25 mm). Stimuli applied just adjacent to the recording site produced nearly centrifugal propag...

Action potential-independent transmitter release is random and produces small depolarizations in the postsynaptic neuron. This process is, therefore, not thought to play a significant role in impulse propagation across synapses. Here we show that calcium flux through presynaptic neuronal nicotinic receptors leads to mobilization of store calcium by calcium-induced calcium release. Recruitment o...

In hippocampal CA1 pyramidal neurons, action potentials generated in the axon back-propagate in a decremental fashion into the dendritic tree where they affect synaptic integration and synaptic plasticity. The amplitude of back-propagating action potentials (b-APs) is controlled by various biological factors, including membrane potential (Vm). We report that, at any dendritic location (x), the ...

Simulation of action potential propagation on cardiac tissues represents both a computational and memory intensive task. The use of detailed ionic cellular models, combined with its application into threedimensional geometries turn simulation into a problem only affordable, in reasonable time, with High Performance Computing techniques. This paper presents a complete and efficient parallel syst...

A two-dimensional atrial tissue model has been constructed to study the propagation of action potential and electrograms. The model presents the atrial electrograms recorded with a mapping catheter. The model can be stimulated to produce an action potential identical to human electrograms. The model is simulated using the Courtemanche et al. cell model equations. The electrical propagation of t...

During low-frequency firing, action potentials actively invade the dendrites of CA1 pyramidal neurons. At higher firing rates, however, activity-dependent processes result in the attenuation of back-propagating action potentials, and propagation failures occur at some dendritic branch points. We tested two major hypotheses related to this activity-dependent attenuation of back-propagating actio...

Available models of circus movement reentry in cardiac muscle and of drug action on reentrant arrhythmias are based on continuous medium theory, which depends solely on the membrane ionic conductances to alter propagation. The purpose of this study is to show that the anisotropic passive properties at a microscopic level highly determine the propagation response to modification of the sodium co...

We suggest that the propagation of the action potential is driven by a pressure pulse propagating in the axoplasm along the axon length. The pressure pulse mechanically activates Na ion channels embedded in the axon membrane. This activation initiates the development of a local membrane voltage spike, as in the Hodgkin-Huxley model of the action potential. Extracellular Ca ions influxing during...