Background Genomic profiling is increasingly incorporated into oncology research and the clinical care of cancer patients. We sought to determine physician perception and use of enterprise-scale clinical sequencing at our center, including whether testing changed management and the reasoning behind this decision-making. Patients and methods All physicians who consented patients to MSK-IMPACT,...

Background: With the growing use of electronic health record systems, there is a demand for an electronic version of the leading American pediatric preventive care guideline, Bright Futures. As computer implementation requires actionable recommendations, it is important to assess to what degree Bright Futures meets criteria for actionability. Objectives: We aimed to 1) determine the number of a...

Pattern-driven analytics and mining has received a lot of attention in the last two decades, because information discovered data can be used to support decision strategy making [...]

Extraction of knowledge from data and using it for decision making is vital in various real-world problems, particularly in the financial domain. We identify several financial problems, which require the mining of actionable subspaces defined by objects and attributes over a sequence of time. These subspaces are actionable in the sense that they have the ability to suggest profitable action for...

BACKGROUND The effectiveness of molecular targeted agents is modest in hepatocellular carcinoma (HCC). Efficacy of molecular targeted therapies has been better in cancer patients with high expression of actionable molecules defined as cognate target molecules. However, patient stratification based on the actionable molecules dictating the effectiveness of targeted drugs has remained understudie...

OBJECTIVE To retrospectively evaluate the features of undiagnosed breast cancers on prior screening breast magnetic resonance (MR) images in patients who were subsequently diagnosed with breast cancer, as well as the potential utility of MR-computer-aided evaluation (CAE). MATERIALS AND METHODS Between March 2004 and May 2013, of the 72 consecutive pairs of prior negative MR images and subseq...

BACKGROUND With the growing use of electronic health record systems, there is a demand for an electronic version of the leading American pediatric preventive care guideline, Bright Futures. As computer implementation requires actionable recommendations, it is important to assess to what degree Bright Futures meets criteria for actionability. OBJECTIVES We aimed to 1) determine the number of a...

BACKGROUND Implantable loop recorders (ILRs) are conventionally utilized to elucidate the mechanism of atypical syncope. The objective of this study was to assess the impact of these devices on management of pediatric patients with known or suspected inherited arrhythmia syndromes. METHODS AND RESULTS A retrospective chart review was undertaken of all pediatric patients with known or suspecte...

Sequencing-based breast cancer diagnostics have the potential to replace routine biomarkers and provide molecular characterization that enable personalized precision medicine. Here we investigate the concordance between sequencing-based and routine diagnostic biomarkers and to what extent tumor sequencing contributes clinically actionable information. We applied DNA- and RNA-sequencing to chara...