BACKGROUND AND AIMS Quercetin is a flavonoid with good antioxidant activity, and exhibits various important pharmacological effects. The aim of the present work was to study the influence of formulation factors on the physicochemical properties of quercetin-loaded polymeric nanoparticles in order to optimize the formulation. MATERIALS AND METHODS The nanoparticles were prepared by the nanopre...

Purpose – The aim of the article is to diagnose export and import activity Polish voivodships through prism spatial concentration, investigate whether diversification index same as index, loses its methodological value in determining both due difficulties assigning trade flows a specific voivodeship. Reseach method contains an analysis based on review literature calculations regarding concentra...

Fluoxetine (FLX), a P-glycoprotein inhibitor with antimalarial activity, is promising candidate for reversing chloroquine/mefloquine (CQ/MQ) resistance. The Dd2 strain of CQ- and MQ-resistant Plasmodium falciparum was synchronized and assayed with various concentrations of CQ/MQ individually and in combination with FLX or verapamil (VPL). Our results indicated the 50% inhibitory concentration v...

cadmium is considered as a common residue in water and sediments which could readily enter aquatic organisms. the aim of this study was to evaluate the time- and concentration-dependent changes in antioxidant enzymes (sod and cat) activities as well as concentration of mda as a bi- product of lipid peroxidation in the liver of persian sturgeon, acipenser persicus , following cdcl 2 exposure at ...

Effects of chemical structure, concentration, and pH on antimicrobial activity conjugated bile acids were investigated in 4 strains lactobacilli. Considerable differences observed the between 6 human acids, including glycocholic acid, taurocholic glycodeoxycholic taurodeoxycholic glycochenodeoxycholic taurochenodeoxycholic acid. Glycodeoxycholic acid generally showed significantly higher agains...

Increased incidence of adrenal pheochromocytoma is frequently encountered in rat carcinogenicity studies. In some of the studies, the finding is judged to be due to a rat-specific mechanism of carcinogenesis caused by a disturbance of calcium homeostasis. However, direct evidence that the proliferation of chromaffin cells in the adrenal medulla is induced solely by hypercalcemia is not availabl...