Aberrant cell-cycle activity and DNA damage are emerging as important pathological components in various neurodegenerative conditions. However, their underlying mechanisms are poorly understood. Here, we show that deregulation of histone deacetylase 1 (HDAC1) activity by p25/Cdk5 induces aberrant cell-cycle activity and double-strand DNA breaks leading to neurotoxicity. In a transgenic model fo...

OBJECTIVE The primary objectives of the present study were to (1) contrast reproductive hormone levels and ratings of menstrual distress of female migraineurs with those of a control group in each menstrual cycle phase, (2) examine correlations between hormone levels and migraine frequency, severity, and migraine-related disability, and (3) examine correlations between menstrual distress and mi...

Peripheral tinnitus is a good candidate for inclusion under the NO/ONOO – cycle etiological mechanism, fitting each of the five principles of this mechanism. Cases of tinnitus are initiated by at least 11 short-term stressors increasing nitric oxide or other cycle mechanisms. Such cycle elements as N -methylD -aspartate activity; oxidative stress; nitric oxide; peroxynitrite; vanilloid activity...

in our search for new anticancer medicinal plants, the antiproliferative activity of the methanol extract of daphne mucronata (thymelaeaceae) was evaluated using human myelogenous leukemia k562 cells. the cells responded to plant treatments in a dose dependent manner and the ic50 of the crude extract (equivalent to 1 g of plant leaves powder per ml) and the purified active component were found ...

Since the beginning of space age, Sun has been in a multi-cycle period elevated activity (secular maximum). This secular maximum is longest last 9300 years. end solar cycle 21 (SC21), however, shown decline overall activity, which remarkably increased fluxes galactic cosmic rays (GCRs). Here, we investigate correlation between modulation GCRs, heliospheric magnetic field, and wind speed for 24 ...

the purpose of this study was to investigate and compare whether the explant supernatants prepared from endometrial tissues during the proliferative phase, secretory phase and early pregnancy differ in immunosuppressive activity. specimens of nonpregnant endometrium from hysterectomies and normal first trimester decidua following elective aspiration termination of pregnancy were obtained. super...

The present work was carried out to investigate first, the ecology of the Sepedon flies as well as speciesof Lymnea snails and secondly, the biological effects of Sepedon fly larvae living on Lymnea. In this regard,the life cycle, death rate and compatibility of Lymnea species, as well as the life cycle of Sepedon flies inbreeding cage and the activity of the new larvae in the same ecological c...