Leukocytes express a major sialoglycoprotein, leukosialin, of which the apparent molecular weight (mol wt) can be variable according to the differences in 0-glycans attached to this molecule. In the present study, we analyzed the structures of 0-glycans attached to leukosialin present in various T-lymphocytic leukemia cells. T-lymphoid cells from patients with acute T-lymphocytic leukemia expre...

Karyotypes were analyzed by routine Giemsa and quinacrine fluorescence for 16 patients with acute lymphocytic leukemia [ten adults (18 to 51 years) and six children (3 to 15 years)]. Four patients had received previous therapy, but all 16 had active disease when they were first studied. Eight patients (five untreated) had a normal karyotype initially; however, three of these developed a chromos...

Recently, it has been shown that the homozygous deletion of the cyclin-dependent kinase-4 inhibitor (CDK4I;p16) gene, which is mapped to chromosome 9p21, is frequently observed in a wide spectrum of human cancers, including leukemias. Therefore, the CDK4I gene is thought to be a putative tumor-suppressor gene. We report here that both alleles of the CDK4I gene were completely or partially delet...

Karyotypes were analyzed by routine Giemsa and quina cnine fluorescence for 16 patients with acute lymphocytic leukemia [ten adults (18 to 51 years) and six children (3 to 15 years)]. Four patients had received previous therapy, but all 16 had active disease when they were first studied. Eight patients (five untreated) had a normal karyotype initially; however, three of these developed a chromo...

ECG, electrocardiogram; CT, computed tomography; M1, acute myeloid leukemia without differentiation; WBC, white blood cells; WHO, World Health Organization; CK-MB, creatine kinase–myocardial band; CBC, complete blood count; APL, acute promyelocytic leukemia; AML, acute myelocytic leukemia; ALL, acute lymphocytic leukemia; CD, cluster of differentiation; HLA-DR, human leukocyte antigen–D related...

A research project was carried out at Institute of Radiotherapy and Nuclear Medicine (IRNUM) Peshawar, in order to investigate the prevalence of different types of leukemias in North West Frontier Province of Pakistan, during 2001. During this study 60 leukemia patients admitted at IRNUM were investigated. It was found that acute leukemia was more prevalent than chronic leukemia as 90% of total...

chronic lymphocytic leukemia (cll) and chronic myeloid leukemia (cml) are the most common leukemias of the elderly (>43 year). however, the sequential occurrence of cml followed by cll in the same patient is extremely rare. in our report, a 52-year-old female was diagnosed with cll (type of bone marrow (bm) infiltration was nodular and interstitial) and was treated with chlorambucil. 64 months ...

Pegaspargase is used to treat acute lymphocytic leukemia (ALL). Pegaspargase definitely has its benefits in treating ALL; however we cannot lose sight of one of its very rare but potentially deadly complications, acute pancreatitis. Clinicians should monitor triglycerides while the patient is on treatment with Pegaspargase and suspect acute pancreatitis if the patient develops abdominal pain. I...