myeloid sarcoma or granulocytic sarcoma (gs) is a rare disease with poor prognosis. it is characterized by the occurrence of tumor masses at an extra-medullary tissue. it is composed of myeloblastic cells and usually occurs in association with acute myeloid leukemia. because of its nonspecific clinical and radiologic findings, its diagnosis might be challenging. it might be more commonly found ...

Human leukemic cells were tested for fragility by physical agents. The results obtained from this study are summarized as follows: (a) acute monocytic leukemia was relatively resistant to the hyperthermic and hypotonie states; (b) acute myeloblastic leukemia was fragile to the hyperthermic state and resistant to the hypotonie state; (c) acute lymphoblastic leukemia was fragile to both the hyper...

Leukemic blasts from patients with acute nonlymphoid leukemia were examined for the presence of Ig, receptors for IgGFc, and for their capacity to mediate antibody-dependent cellular cytotoxicity (ADCC) against chicken red blood cells (RBC) coated with IgG and spontaneous cell-mediated cytotoxicity (SCMC) against cells of K562 cell line. Leukemic blasts from acute myeloblastic leukemia (AML) pa...

A comparison was made between the agar and methylcellulose culture systems with respect to their ability to support the clonal growth of leukemic cells obtained from patients with acute myeloblastic leukemia, acute lymphoblastic leukemia, and chronic myelogenous leukemia in blastic crisis. The num ber of clusters and/or colonies formed and the morphology of the cells within them varied from pat...

A comparison was made between the agar and methylcellulose culture systems with respect to their ability to support the clonal growth of leukemic cells obtained from patients with acute myeloblastic leukemia, acute lymphoblastic leukemia, and chronic myelogenous leukemia in blastic crisis. The number of clusters and/or colonies formed and the morphology of the cells within them varied from pati...

Absent or diminished HLA-Dr antigen representation on the cell surface of both normal and leukemic promyelocytes is a hallmark of this stage of myeloid maturation. In order to document the specificity of this finding for acute promyelocytic leukemia, flow cytometric analysis of leukemic blasts was utilized on 36 cases of acute non-lymphocytic leukemia. All 15 of the promyelocytic leukemias (FAB...

By means of the direct fluorescent antibody technique it was shown that malignant cells in acute lymphoblastic leukemia do not, as a rule, bear immunoglobulins on the cell surgace (43 of 45 cases). During complete remission the number of Ig-positive cells corresponds to the number of Ig-positive cells in normal lymphocyte populations. During incomplete remission as well as during incomplete rem...

Terminal deoxynucleotidyl transferase activity, immunologic membrane markers, and cytochemical reactivity were examined in blasts of 80 adults with acute leukemia. The study was interinstitutional and prospective so that some assessment could be made of the usefulness and practicality of these tests in the classification of adult acute leukemias. Initial classification as to the type of acute l...