purpose : the aim of this study is to measure the endogenous cortisol levels in the patients with central serous chorioretinopathy (cscr) and also, evaluate the short-term effect of oral ketoconazole in the treatment of both acute and chronic cscr. methods : in this prospective interventional case series 12 patients with acute cscr and 7 patients with chronic cscr (including one patient with bi...

Flavone analogs are natural compounds of the flavonoid class that have a wide range biological activities. The present study aimed to predict, with aid in silico methodologies, oral bioavailability and pharmacokinetic toxicological analyzes for three flavone analogues (apigenin, chrysin luteonlin). revealed good availability, favorable parameters. Virtual Screening performed predict all did not...

Journal of Veterinary Pharmacology and TherapeuticsVolume 46, Issue S1 p. 32-32 ORAL PRESENTATIONS O10 | The importance preregistration for animal-based research First published: 11 June 2023 https://doi.org/10.1111/jvp.13176Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare text full-text accessPlease review our Terms Con...

INTRODUCTION: Despite medical developments, drug poisoning still occurs. Lithium is a that has been used for more than 60 years as mood stabilizer in the treatment and prevention of bipolar disorder, mania recurrent depression. most commonly prescribed stabilizer. It narrow therapeutic index. Its target concentration acute should be 0.6-1.5 mEq/L 0.6-0.8 maintenance therapy. Because this, there...

The Björn Ekwall Memorial Foundation (BEMF) was initiated by the Scandinavian Society for Cell Toxicology in 2001, to honour the memory of Dr Björn Ekwall (1940-2000) and to establish a prize, the Björn Ekwall Memorial Award. The prize is awarded to scientists who have significantly contributed to the field of cell toxicology, and whose work is contributing toward the replacement of animal expe...

Previous studies of cocaine use and stroke have focused on acute effects of cocaine in perceived high-risk populations. We characterized mechanisms and risk factors for cocaine use among ischemic stroke patients from a broad range of socioeconomic backgrounds to inform medical management decisions and prevention efforts. We studied consecutive adults admitted with acute ischemic stroke to our i...

Methamphetamine has been reported to be an important drug in the field of reproductive toxicology. The aim of this study was to investigate the effects of methamphetamine administrations on sperm morphology, sperm concentration and apoptotic activity inside seminiferous tubule in male rats. Rats were administered a dose of 8 mg kg(-1) , intraperitoneally (IP), for acute group and a dose of 4 mg...

In the last issue of Asia Pacific Journal of Medical Toxicology (APJMT), editor-in-chief, Dr. Reza Afshari focused on an important contemporary issue of empowering toxicology in the Asia pacific region (1). The topic drew our attention and we would like to share the situation of Bangladesh in light of this editorial. Dr. Afshari correctly emphasized on forming national societies of medical toxi...