Values for total lactate dehydrogenase (LD, EC 1.1.1.27) and LD isoenzyme-5 were determined in serum of 106 patients with benign hepatic disorders, 54 of whom had acute liver disorders, either acute hepatitis (39 patients) or acute circulatory disturbances (15 patients). Fifty-two had chronic hepatic disorders, either cirrhosis (25 patients) or chronic right heart failure (27 patients). Overall...

Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute and severe decompensation of chronic disease (CLD) correlated with multiple organ failure, poor prognosis, increased mortality. In 40–50% ACLF cases, the trigger not recognized; for many these patients, bacterial translocation associated systemic inflammation thought to be determining factor; in other 50% sepsis, alcohol...

Background: Serial measurement of  hepatitis B virus (HBV) DNA levels in the liver and its relation with liver damage and serum HBV DNA levels are guide to begin and/or end a treatment course. This study evaluated the relationship between liver hepatitis B DNA viral load with liver histology in patients with chronic hepatitis B (HBV). Methods:  Thirty patients with chronic anti-Hbe positive ...

Introduction: There is variability of data regarding seroprevalence and coinfection of hepatitis viruses. Our objective was to determine the magnitude, pattern and coinfection of hepatitis viruses in clinically suspected cases of acute infectious hepatitis. Methods: This descriptive study was conducted in the Department of Microbiology at Lady Hardinge Medical College, New Delhi, over a period ...

Genotyping and subtyping are important to understand epidemiology of the hepatitis E virus so as to improve control measures to prevent transmission of virus in the community. Hence, the aim of the current study was to identify the prevalent HEV genotypes in Rajasthan in acute sporadic hepatitis E cases with varying degree of liver failure. We studied hepatitis E virus (HEV) isolates from hospi...

conclusions there are few studies on the prevalence of viral hepatitis in the general population of iran. most of the reports are from specific groups of patients. further epidemiologic studies on the general population of iran are recommended to discover the real burden of viral hepatitis. context viral hepatitis is still considered as a major health concern. defining the extent of the burden ...

Viral hepatitis is a major problem in Egypt. To define the epidemiology of the disease, sentinel surveillance was established in 5 hospitals in diverse areas of the country in 2001. Data were completed for patients meeting the case definition for viral hepatitis. Of a total of 5909 patients evaluated, 4189 (70.9%) showed positive antibody markers for hepatitis. Out of those, 40.2% had evidence ...

800x600 background : hepatitis b and c infections have remained major global health burdens during the most recent century. the viral agents responsible for these diseases share common modes of transmission with human immunodeficiency virus (hiv) such as needle-sharing in iv drug abusers. coinfection of hepatitis b or c with hiv increases the rate of progression of chronic liver disease. given ...

BACKGROUND Afghanistan's public health system was neglected during decades of military and civil conflict, and trends in infectious disease occurrence remain poorly characterized. This study examines cyclical and long-term trends of six vaccine-preventable diseases: pneumonia, diarrhea, meningitis, typhoid, measles, and acute viral hepatitis. METHODS Using weekly data collected between 2009 a...

Liver biopsy plays a central role in treatment algorithms in patients with hepatitis B and remains the gold standard for evaluating hepatic pathology. The pathology of hepatitis B is diverse and reflects the natural history of infection. An acute hepatitic pattern with lobular disarray is seen in acute infection, during acute flares of disease, and with acute hepatitis D superinfection. In chro...