introduction: unstable angina as a clinical condition includes a major group of patients manifested with acute coronary syndrome. misdiagnosis of this clinical syndrome causes myocardial infarction (mi) and death. conventional and advanced forms of treatment are used with the aim of rapid stabilization of unstable angina. although infusion of glucose - insulin - potassium (gik) solution has had...

background: unstable angina and myocardial infarction are developed due to atherosclerosis of coronary arteries. at present, cholestrol, triglyceride, and lipoproteins are the most common risk factors of death. the purpose of this study was to assess the serum levels of lp (a), ldl-c, vldl-c, hdl-c in cases of unstable angina and myocardial infarction.methods: this study was conducted to compar...

there are several reports that adenosine and carbamazepine have pharmacodynamic interaction. i n this study the antinociceptive interaction o f these two agents was evaluated in mice by the hot plate test. agents were injected intraperitoneally. 0.2 and 0.4 mg/kg doses of r-phenylisopropyladenosine (r-pia) substantially showed antinociceptive effects. carbamazepine had antinociceptive actions e...

BACKGROUND In patients with stable angina pectoris aminophylline, a nonselective antagonist of adenosine receptors, markedly improves exercise capacity. To establish the role played by A1 adenosine receptors in the anti-ischemic action of aminophylline, the effects of bamiphylline, a selective A1 antagonist, on exercise-induced ischemia were investigated in patients with stable angina pectoris....

BACKGROUND The pathophysiology of microvascular response to a severe coronary stenosis has not been conclusively identified. The aim of this study was to characterize the human vasomotor response to pacing-induced ischemia of both the stenotic arterial segment and the distal microcirculation. METHODS AND RESULTS Sixteen patients with stable angina and single-vessel disease were studied. Blood...

BACKGROUND Recent studies suggest that patients with angina before myocardial infarction exhibit improved recovery of coronary perfusion after thrombolysis by an as-yet-unknown mechanism. We therefore proposed that brief antecedent ischemia/reperfusion may, via release of adenosine, improve vessel patency in damaged and stenotic coronary arteries. METHODS AND RESULTS Anesthetized dogs underwe...

BACKGROUND In cardiac syndrome X (a syndrome characterized by typical angina, abnormal exercise-test results, and normal coronary arteries), conventional investigations have not found that chest pain is due to myocardial ischemia. Magnetic resonance techniques have higher resolution and therefore may be more sensitive. METHODS We performed myocardial-perfusion cardiovascular magnetic resonanc...

OBJECTIVE Unlike currently approved adenosine diphosphate receptor antagonists, the new diadenosine tetraphosphate derivative GLS-409 targets not only P2Y12 but also the second human platelet adenosine diphosphate receptor P2Y1 and may, therefore, be a promising antiplatelet drug candidate. The current study is the first to investigate the in vivo antithrombotic effects of GLS-409. APPROACH A...