The activity of phenylethanolamine-N-methyl transferase, an enzyme that synthesizes adrenaline from noradrenaline in the adrenal medulla, is markedly depressed following hypophysectomy. Enzyme activity is restored to normal after administration of ACTH or the potent glucocorticoid, dexamethasone. Thus the biosynthesis of adrenaline in the adrenal medulla appears to be regulated by the pituitary...

MOJ Toxicol 2016, 2(2): 00032 Abbreviations: ADHD: Attention Deficit and Hyperactivity Disorder; CNS: Central Nervous System; CPRS: Conners’ Parent Rating Scale; CTRS: Conners’ Teachers Rating Scale; HPA: Hipothalamo Pituitary Adrenal Axis; HPAS: Hacettepe Psychological Adaptation Scale; PNPM: p-Nitrophenyl α-maltoside; sAA: α-amylase; SAM: Sympathetic Adrenal Medulary; STAI: State Trait Anxiet...

21-hydroxylase deficiency (21-OHD) caused congenital adrenal hyperplasia (CAH) is a group of autosomal recessive genetic disorders resulting from mutations in genes involved with cortisol (CO) synthesis in the adrenal glands. Testicular adrenal rest tumors (TARTs) are rarely the presenting symptoms of CAH. Here, we describe a case of simple virilizing CAH with TARTs, in a 15-year-old boy. The p...

Adrenal insufficiency is characterized by decreased production of glucocorticoids from adrenal cortex, either due to a primary or secondary pituitary etiology. Neuropsychiatric symptoms and signs could be the first presenting only presentation are relatively less explored in patients with understood. Patients chronic psychiatric symptoms, namely depression anxiety should evaluated for associati...

El objetivo de este trabajo fue resaltar la importancia del diagnóstico causa síndrome Cushing, en un paciente canino macho, 12 años edad, con carcinoma cortical adrenal, que llega a consulta por presentar signos clínicos compatibles Síndrome Cushing. Los resultados estimulación ACTH sintética (Synacthen 0.25 mg®) arrojaron aumento el cortisol basal (10.8 µg/dl) y pos-estimulación (28.4 µg/dl)....

Adrenal Crisis is an acute deterioration of adrenal insufficiency. This condition leads to emergency condition. The major manifestation crisis hypotension and shock hypovolemic. Unspecified general would lead misdiagnosis suboptimal management this Comprehensive understanding, early diagnosis, prompt are important prevent morbidity mortality risks in children with crisis.

introduction: it has been demonstrated that the adrenal medullary transplants into the spinal subarachnoid space can alleviate neuropathic pain behaviors. the aim of the present study was to test the possibility that histological changes of the sciatic nerve in a neuropathic model as well as sensory dysfunction are repaired by adrenal medullary transplantation. material and methods: left sciati...

background: noise pollution is considered as a stressful factor in every day’s life of the industrial world. the present study was designed to investigate the probable effects of different time exposure of noise stress on histomorphometric changes of adrenal gland, plasma cortisol and body weight of the rat.   methods: sixty adult male wistar rats were divided into two series of short time nois...

The adrenal gland is an essential stress-responsive organ that is part of both the hypothalamic-pituitary-adrenal axis and the sympatho-adrenomedullary system. Chronic stress exposure commonly increases adrenal weight, but it is not known to what extent this growth is due to cellular hyperplasia or hypertrophy and whether it is subregion specific. Moreover, it is not clear whether increased pro...