OBJECTIVE To determine whether the nocturnal fall in plasma adrenaline is a cause of nocturnal asthma. DESIGN Double blind placebo controlled cross-over study. In the first experiment the nocturnal fall in plasma adrenaline at 4 am was corrected in 10 asthmatic subjects with an infusion of adrenaline after parasympathetic blockade with 30 micrograms/kg intravenous atropine. In the second expe...

BRtlCKE, Kaindl and Mayer 1 showed in 1952 that hypothalamic stimulation in the cat increased the adrenaline percentage of catechol amines in adrenal venous blood from about 11 per cent in the "resting" secretion to about 50 per cent. Since there is no consistent alteration in the adrenaline percentage during the increased secretion following carotid occlusion in the cat, the results of Briicke...

中谷 〓二 It was reported previously (1) that an increase in heart phosphorylase a following the intravenous administration of adrenaline in a dose of 10.0 ƒÊg/kg was less than that following 1.0 ƒÊg/kg, and that atropinization or vagotomy potentiated the phosphorylase activating action of adrenaline. In addition, a significant elevation of heart phospho rylase a was maintained for 2 hours after th...

High concentrations of circulating biogenic catecholamines often exist during the course of several cardiovascular disorders. Additionally, coronary dysfunctions are prominent and frequently related to the ischemic and reperfusion phenomenon (I/R) in the heart, which leads to the release of large amounts of catecholamines, namely adrenaline, and to a sustained generation of reactive oxygen spec...

Adrenaline (epinephrine) has been used for cardiopulmonary resuscitation since 1896; the rationale behind its use is thought to be its α-adrenoceptor-mediated peripheral vasoconstriction, causing residual blood-flow to be diverted to coronary and cerebral circulations. This protects these tissues from ischaemic damage and increases the likelihood of restoration of spontaneous circulation. Clini...

1. Plasma noradrenaline and adrenaline concentrations and plasma renin activity were measured in 21 mothers at delivery and in their babies at birth (umbilical cord blood) and on days 1 and 5 of extrauterine life. 2. At birth plasma renin activity was significantly higher in the newborn than in mothers. Plasma renin activity increased further, but not significantly, on day 1 of life and signifi...

To determine the contribution of plasma catecholamines to the cardiovascular effects of elevated levels of angiotensin II (Ang II) in trout, this study investigated (1) the stimulatory effects of [Asn1-Val5]-Ang II on plasma catecholamine levels, (2) the cardiovascular effects of Ang II with and without alpha-adrenoceptor blockade and (3) the relationship between plasma adrenaline concentration...

Cerebral non-oxidative carbohydrate consumption may be driven by a β2-adrenergic mechanism. This study tested whether the 46G > A (G16R) single nucleotide polymorphism of the β2-adrenergic receptor gene (ADRB2) influences the metabolic and cerebrovascular responses to administration of adrenaline. Forty healthy Caucasian men were included from a group of genotyped individuals. Cardio- and cereb...