A MULTI-AGENT INTELLIGENT SYSTEM FOR DETECTING UNKNOWNADVERSE DRUG REACTIONS THROUGH COMMUNICATION ANDCOLLABORATIONby AYMAN MANSOURDecember 2012 Advisor: Prof. Hao YingMajor: Electrical EngineeringDegree: Doctor of PhilosophySeveral thousands of drugs are currently available on the U.S. market. A completeunderstanding of the safe use of drugs is not possible at t...

BACKGROUND In drug development, animal toxicology data are very important for the evaluation of clinical safety. We quantitatively assessed the safety profiles of blood cancer drugs approved in Japan from category I (high) to V (low). We examined the ratios of drug exposure in animals at the no observed adverse effect level to those in humans at the expected therapeutic dose. In addition, quali...

Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. ADRs induced by several drugs...

Adverse drug reactions (ADRs) are considered as one of the leading causes of death among hospitalized patients. Thus reporting of adverse drug reactions become an important phenomenon. Spontaneous adverse drug reaction reporting form is an essential component and a major tool of the pharmacovigilance system of any country. This form is a tool to collect information of ADRs which helps in establ...

PURPOSE To explore the association between the use of neuroactive drugs and reports of epileptic seizures. MATERIAL Using the WHO adverse drug reactions (ADR) database, VigiBase, we surveyed reports of suspected seizures from 1968 until February 2006. Case reports of ADRs, that were classified as convulsions were collected and compared to the total number of ADRs reported. RESULTS The total...

BACKGROUND AND PURPOSE No previous systematic evaluation of antimicrobial-related adverse drug reactions (ADRs) in Taiwanese patients has been reported. The present study aimed to assess the incidence, risk factors, clinical manifestations, and causative agents of antimicrobial-ADRs in hospitalized patients. METHODS 299 patients who received antimicrobial treatment during hospitalization in t...

OBJECTIVE The aim of this study was to provide a systematic safety analysis of gadobutrol after more than 29 million applications in clinical routine. MATERIALS AND METHODS Forty-two clinical development phase II to IV studies on gadobutrol or comparator and the postmarketing safety surveillance database for gadobutrol (1998-2015) were analyzed. Adverse events (AEs) and drug-related AEs were ...

Objective. To perform pharmacoepidemiological analysis of spontaneous reports adverse drug reactions (ADRs) occurred during macrolide group antibiotics prescription and registered in the “Pharmacovigilance 2.0” subsystem Federal Service for Surveillance Healthcare. Materials Methods. A retrospective ADRs arising from use all azalide Russia electronic database Healthcare period 01.04.2019 to 30....

PURPOSE Bioequivalent medications are required by the Food and Drug Administration to have identical warnings on their labels. This requirement has both clinical and legal importance, yet has never been validated. We sought to determine the real-world consistency of electronic labeling for bioequivalent drugs from different manufacturers. METHODS Using natural language processing, we indexed ...

Objectives: To assess the Knowledge, Attitude and Practices of nursing students on monitoring reporting adverse drug reactions in a tertiary care hospital. Methodology: This questionnaire based study was conducted hospital 85 Prefinal final year students. The instrument pre designed which included Knowledge ADRs reporting, attitudes towards factors could hinder reporting. were given an educativ...