In the present study, the possible interactions between celecoxib and some excipients (colloidal silicon dioxide (Aerosil), microcrystalline cellulose (Avicel PH 102), lactose anhydrous, magnesium stearate, cross-povidone and talc) were evaluated by examining the pure drug or drug-excipient powder mixtures which were stored under different conditions (25 +/- 2 degrees C, 60% RH +/- 5% RH or 40 ...

This study was aimed at developing risperidone oral disintegrating mini-tablets (OD-mini-tablets) as age-appropriate formulations and to assess their suitability for infants and pediatric use. An experimental Box-Behnken design was applied to assure high quality of the OD-mini-tablets and reduce product variability. The design was employed to understand the influence of the critical excipient c...

A high-resolution calorimetric study has been made on the smectic-A to nematic phase transition in liquid crystals perturbed by the dispersion of 70-Å-diam silica spheres ~aerosils!. The specific heat peak of this transition decreases in amplitude and shifts to lower temperatures with increasing silica density. However, it remains sharp in comparison to the effects of aerogel confinement at the...

It had became a challenging experience and effort for formulator to develop innovate drug with maximum bioavailability. In the present study focus of research is in treatment Hypertension, which one most prevalent cardiovascular diseases world, affecting big proportion adult old age population. Candesartan Cilexetil angiotensin II AT1 many tissues including vascular smooth muscle adrenal glands...

Black cumin seed oil (MBJH) ( Nigella sativa L .) is a well-known herb with pharmacology activities such as anticancer and anti-thrombocytopenia. The limitation of MBJH has poor absorption when using oral dosage form. liquid SNEDDS (Self-nanoemulsifying drug delivery system) an alternative formulation. However, the disadvantage liquid-SNEDDS MJBH was interaction between active ingredients soft ...

The aim of present study was to improve the solubility of pioglitazone HCl a practically insoluble antidiabetic drug by using liquisolid technique. The in vitro release pattern of liquisolid tablets and directly compressed tablets were studied using USP-II apparatus. Different Liquisolid tablets were prepared using a mathematical model to calculate the required quantities of powder and liquid i...

Purpose: To develop rosuvastatin calcium-loaded self-nanoemulsifying powder for improved oral delivery of the drug. Methods: Solubility study was carried out in different oils, surfactants and co-surfactants. Based on the solubility study, liquid formulations were prepared using LAS/Capryol 90: Maisine 35-1 as oil phase and Tween 20 with Lutrol E400 as surfactant mixture (Smix). The liquid form...

Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The aim of this research was to introduce a new glime...