BACKGROUND Although endothelin I (ET-1) is a very potent vasoconstrictor, ET-1 transgenic (ET-1 tg) mice are not hypertensive. This might be due to higher bioavailability of nitric oxide (NO) in ET-1 tg, which counteracts the effect of vasoconstrictors. We hypothesized lower angiotensin II (Ang II) sensitivity of afferent arterioles in ET-1 tg. METHODS Afferent arterioles were manually dissec...

Studies were performed to determine the responsiveness of rat juxtamedullary afferent arterioles to receptor-selective P2-purinoceptor agonists. Experiments were performed in vitro using the blood perfused juxtamedullary nephron technique, combined with videomicroscopy. Renal perfusion pressure was set at 110 mmHg and held constant. Basal afferent arteriolar diameter averaged 22.0 ± 0.6 μm ( n ...

The objective of this study was to determine the contribution of renal nerves to the enhanced afferent arteriolar reactivity observed in angiotensin II (Ang II)-induced hypertension. Uninephrectomized Sprague-Dawley rats were divided into four groups: sham rats, renal-denervated rats, Ang II-infused (at 40 ng/min for 13 days) rats, and Ang II-infused+renal-denervated rats. With the use of an im...

20 Increasing joint stiffness by co-contraction of antagonist muscles or compensatory reflexes are neural 21 strategies to minimize the impact of unexpected perturbations on movement. Combining these strategies, 22 however, may compromise steadiness as elements of the afferent input to motor pools innervating antagonist 23 muscles are inherently negatively correlated. Consequently, a high affer...

introduction: electrophysiologycal histological methods were for studing the anatomical distribution of group i and ii muscle afferent in the lumbosacral segments of wistar rat spinal cord. material and methods: quadriceps, deep proneal, hamestring, gastrocnemius-soleus, tibialis posterior, plantaris, flexor digitorum longus and popliteus muscle nerves were dissected and mounted on surface elec...

introduction: functional ankle instability has described as a “feeling of giving way”. balance control deficit is one of the sensorimotor impairments observed in people with functional ankle instability that has been described to damage to the afferent receptors within the ligaments and joint capsule that affected during sprain. foot orthosis can improve balance control via enhanced sensory aff...

Background: Satiety in the stomach is often caused by distension and satiating feeling triggered through afferent vagal signals. Increasing or prolonging of with a low-calorie agent would be beneficial reducing energy intake potentially aid management weight. The aim this work was to quantify rheological properties an alginate formulation induce satiety (AFIS) as it passes physiologically relev...

Most afferent signals from the viscera do not give rise to conscious experience and yet they participate in the complex neural control of visceral functions. Surprisingly little information is available on the origin, morphology, and receptor functional characteristics of the nerve endings of most primary afferent neurones to the digestive tract. This review deals with the morphological nature ...

I The activity produced by intra-arterial bradykinin and prostaglandin El was investigated in multifibre strands dissected from the saphenous nerves of anaesthetized rats. 2 Bradykinin (0.5-10 gg) alone produced little activity in nerve strands but produced considerable activity following a 10 min infusion, but not a single injection, of prostaglandin E1 (5-100 ng). 3 Prostaglandin E1 alone pro...