conclusions accordingly, it can be concluded that locally low temperatures and acidic conditions are the main suspected reasons for protein misfolding. results based on the study findings the low temperature, 0°c, and acidic condition change the structure more strongly than other mentioned conditions. the low temperature and acidic conditions seem to have the most misfolding effect on insulin s...

liquid protein formulations are prone to form aggregates. the effect of nonionic surfactants such as polysorbate 20 (ps 20) and n-dodecyl β-d-maltoside (ddm) on the prevention of aggregation and conformational changes of recombinant human ifnβ-1b (rhifn β_1b) was explored. polysorbate has been used in formulations of protein pharmaceuticals. there have been concerns about using ps 20 due to its...

in this research, cobalt and nickel sulfide nanoparticles (nps) were grown on almcm-41 matrix by using ion exchange method. the prepared samples were irradiated by thermalized neutron that emitted from am-be source up to fluencies (7.9+e9n/cm2). after that, x-ray diffraction (xrd), uv-vis spectroscopy, fourier transform infrared (ftir), scanning electron microscopy (sem) and transmission electr...

today’s world economy situation forces enterprise organizations toward more soft and flexible organization, management, and production processes. they need to explore the most suitable knowledge management (km) tool not only to identify gaps and overlaps but also to maintain and support innovation cross organizations. in this study, a multiple-experts-multiple-criteria decision making model is ...

introduction: methadone has been used as a drug to detoxify opioid tolerance. naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. on the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking...

The Driver Behaviour Questionnaire (DBQ) is widely used around the world to investigate driving behaviours. However, it has several different versions extracted from the 50-items Manchester driver behaviour questionnaire for variety of societies. This study aims to calibrate the DBQ for the Iranian driver population and explore their aberrant driver behaviour. In total, 524 participants (325 me...

When tobacco is smoked, chewed or snuffed, nicotine is absorbed by the lungs or mucous membrane and quickly moved into the bloodstream, where it is circulated throughout the brain. In fact nicotine is highly dangerous to be consumed in any form. The present study was conducted to know the adverse effects of nicotine on the platelet aggregation in cerebral microvessels of mice. Male mice of aver...