Allergic inflammation is known to cause airway hyperresponsiveness in mice. However, it is not known whether inflammation affects the stiffness of the airway wall, which would alter the load against which the circumscribing smooth muscle shortens when activated. Accordingly, we measured the time course of airway resistance immediately following intravenous methacholine injection in acutely and ...

Twenty subjects with mild asthma were exposed at rest in a body plethysmograph, to NO2 at 0, 260, 510 and 1,000 micrograms.m3, for 30 min on four separate days. Bronchial responsiveness (histamine inhalation test) was measured after each exposure session. Airway resistance (Raw), thoracic gas volume (TGV) and specific airway resistance (sRaw) were measured before, during and after exposure, and...

INTRODUCTION We report a case of postural tachycardia syndrome occurring after the surgical correction of an aortic coarctation, and coexisting with upper airway resistance syndrome. CASE PRESENTATION A 29-year-old Caucasian man complained of extreme fatigue, daytime sleepiness, shortness of breath on exertion, light-headedness and general weakness on standing. These symptoms began shortly af...

Effects of anti-asthmatic drugs on airway resistance and plasma level of cyclic AMP were investigated in guinea pigs sensitized and non-sensitized with egg-albumin. Histamine increased airway resistance in the both groups of guinea pigs, and guinea pigs sensitized with egg-albumin were more sensitive to histamine. Anti-asthmatic drugs inhibited dose-dependently the increase of airway resistance...

HOW DOES ALTERATION OF AIRWAY RESISTANCE AFFECT DELIVERED TIDAL VOLUME IN ADULT PATIENTS RECEIVING HIGH-FREQUENCY OSCILLATORY VENTILATION (HFOV)? Concerns exist regarding the ability of HFOV to provide the needed lung protective ventilation for adult patients with ARDS. HFOV is increasingly being used as a lung protecting ventilation mode even if some of its protective attributes may be lost as...

INTRODUCTION Patients with the upper airway resistance syndrome are frequently overlooked, and even if clinically suspected, often escape identification by polysomnographic monitoring. CLINICAL PICTURE Three cases (2 women and a man) with excessive daytime sleepiness and fatigue were confirmed to have the upper airway resistance syndrome after undergoing polysomnography with oesophageal press...