The crystal structures of the ligand binding domain of human vitamin D receptor (VDR) complexed with its natural ligand or the superagonists MC1288 or KH1060 have recently been reported. The crystallized ligand binding domain (LBD) of VDR, however, differs from the full-length VDR with respect to deletion of 50 amino acids between its helices 2 and 3. In this study, we investigated structurally...

The 1,25-dihydroxyvitamin D3 [1,25-(OH)2vitamin D3] analog KH1060 exerts very potent effects on cell proliferation and cell differentiation via the vitamin D receptor (VDR). However, the activities of KH1060 are not associated with an increased affinity for the VDR. We now show that increased stabilization of the VDR-KH1060 complex could be an explanation for its high potencies. VDR half-life s...

This paper begins a series studying D-modules on the Feigin-Frenkel semi-infinite flag variety from the perspective of the Beilinson-Drinfeld factorization (or chiral) theory. Here we calculate Whittaker-twisted cohomology groups of Zastava spaces, which are certain finite-dimensional subvarieties of the affine Grassmannian. We show that such cohomology groups realize the nilradical of a Borel ...

La política de cohesión es la principal manifestación del principio solidaridad en Unión Europea. Se trata uno los ámbitos más relevantes acción integración. Este artículo analiza el Reglamento (UE) 2021/1060 Parlamento Europeo y Consejo, 24 junio 2021, con objeto discernir cuáles han sido cambios producidos su misión gestión fondos para periodo programación 2021-2027.