conclusions according to the results of this meta-analysis, there was a high risk of nafld in women with pcos. we suggest evaluating patients with pcos regarding nafld. results we finally included seven eligible studies. according to chi-squared test, there was a significant heterogeneity (73.6%) between studies (p = 0.001). nafld prevalence was significantly higher in patients with pcos compar...

background: increasing evidence suggests an association between ele­vated serum aminotransferase levels and metabolic disorders (metabolic syndrome, hyperlipemia and diabetes mellitus). however, the significance of relatively low levels of aminotransferases in relation to metabolic disorders has not been fully investigated in the general population. we inves­tigated the association between seru...

BACKGROUND The relationship of polymorphisms of the genes that encode for alcohol-metabolizing enzymes and individual vulnerability to alcoholism and alcoholic liver disease (ALD) in women is unclear. We determined the genotypes of ADH1B, ADH1C, CYP2E1 (Dra-I and Pst-I) and ALDH2 in a group of Caucasian Spanish women. METHODS We performed a cross-sectional case-control study. The study group ...

What is Alcoholic Liver Disease? As the name implies, alcoholic liver disease is liver injury attributed to alcohol abuse. The majority of Americans manage to drink alcohol without serious consequences. Research suggests, however, that liver disease may begin to develop after a "threshold" dose of alcohol has been consumed—generally assumed to be four drinks a day (four 12 ounces beers, four gl...

Alcohol is a major cause of liver cirrhosis in the Western world and accounts for the majority of cases of liver cirrhosis seen in district general hospitals in the UK. The three most widely recognised forms of alcoholic liver disease are alcoholic fatty liver (steatosis), acute alcoholic hepatitis, and alcoholic cirrhosis. The exact pathogenesis of alcoholic liver injury is still not clear but...

Background/aims Non-alcoholic fatty liver disease is one of the most common chronic liver diseases. Some risk factors are known to influence the development of non-alcoholic fatty liver disease, but the effect of tobacco smoking on the progression of non-alcoholic fatty liver disease is controversial. The main goal of this systematic review and meta-analysis is to investigate the association be...

BACKGROUND Alcoholic liver disease remains one of the most common causes of chronic liver disease worldwide. The aim of this study was to assess the usefulness of metalloproteinases (MMP1 and MMP13) as diagnostic markers of alcoholic liver disease and to determine the changes in free amino acid profile in the patients with alcoholic liver cirrhosis. MATERIAL AND METHODS Sixty patients with al...

A large proportion of heavy drinkers develop serious alcoholic liver disease. Susceptibility to alcoholic hepatitis and cirrhosis appears to be influenced by heredity, gender, diet, and co-occurring liver illness. Most alcoholic liver damage is attributed to alcohol metabolism. Liver injury may be caused by direct toxicity of metabolic by-products of alcohol as well as by inflammation induced b...

Alcohol consumption and its abuse are significant prevalent cause for liver diseases and death worldwide. Increased bacterial endotoxin in the portal circulation, the plasma ratio of liver enzymes like alanine aminotransferase (ALT), aspartate aminotransferase (AST) and triglyceride implies the symbiotic relation between the gut and liver plays a key function in alcoholic liver disease (ALD). C...

The Practical guideline is based on the current scientific ESPEN Clinical Nutrition in Liver Disease (Plauth M., Bernal W., Dasarathy S., Merli Plank L. D., Schütz T., Bischoff S. C. clinical nutrition liver disease // Clin Nutr. — 2019. 38. ?. 485—521). It has been shortened and transformed into flow charts for easier use practice.
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