introduction: multiple sclerosis (ms) is a progressive and autoimmune neurodegenerative disease of the central nervous system (cns). this disease is renowned through symptoms like inflammation, demyelination and the damage of neurological actions. melittin is one of components of bee venom and has anti-neuroinflammatory effects. curcumin also, a dietary spice from turmeric, has outstanding anti...

this study was undertaken to assess vitamin c status in allergic children. twenty-six allergic patients and 46 apparently healthy controls aged 7-16 years of both sexes were introduced. all patients were diagnosed being allergic based on their histories, physical examinations and laboratory findings. blood samples were obtained between 09.00-11.00 to determine total serum immunoglobulin e, hist...

introduction: chronic rhinosinusitis (crs) is a multifactorial disease. allergies are considered a predisposing factor to crs; however, this remains controversial. the objective of this research was to investigate the prevalence of co-morbidities and allergic reaction, and to specify the most common allergens in patients with confirmed crs.   materials and methods: one hundred patients with sig...

interleukin (il)-35 is a newly discovered suppressive cytokine and has been shown to alleviate  inflammatory  and  autoimmune  diseases.  the  purpose  of  this  study  was  to investigate immunomodulatory capacity of il-35 in patients with allergic asthma.il-35 mrna expression levels in peripheral blood mononuclear cells (pbmcs) were detected  by  quantitative  real-time  pcr  (qpcr).  the  fr...

interleukin (il)-25, a cytokine of il-17 family, can activate p38 mitogen-activated protein kinases(mapk) and nuclear factor(nf)-κb pathways to propagate th2 responses. the allergic rhinitis mouse model was established by stimulating balb/c mouse with ovalbumin (ova). then we detected expression of il-25 and downstream p38mapk and nf-κb. the expression of il-25, p38mapk and nf-κb were detected ...

the pathogenetic mechanism of nasal polyps remains unknown, although allergy has been cited as an important factor in the etiology of nasal polyposis. currently there is no definite histological criterion for differentiation of allergic from inflammatory nasal polyp. however, in a few studies, tissue eosinophil count has been used for this. this study aimed to find out the agreement rate of ski...

allergic rhinitis is the most common cause of allergic diseases. the recent guidelines of allergic rhinitis and its impact on asthma (aria) group, classified it to intermittent (less than 4 days per week and for less than 4 weeks) and persistent (more than 4 days per week or lasting more than 4 weeks regardless of the number of days per week). the present study evaluates the patients with aria ...

Airway eosinophilic inflammation is a characteristic feature of allergic asthma. Exposure to allergens produced by the German cockroach (Blattella germanica) is a risk factor for allergic disease in genetically predisposed individuals, and has been linked to an increase in asthma morbidity among cockroach-sensitive inner city children. To determine the role and contribution of specific HLA clas...

PURPOSE OF REVIEW Biological hypersensitivity to environmental stimuli is a fundamental feature of atopy predisposing to a number of clinically expressed disorders including allergic rhinitis, atopic dermatitis or eczema, and allergic asthma. There is provocative evidence that psychological stress constitutes an increased risk for atopy. This risk is thought to be mediated by the effects of str...

Epstein-Barr virus (EBV) belongs to the family of herpesviruses (herpes type 4) and is one most common highly contagious. During pandemic a new coronavirus disease, it was found that in patients previously infected with EBV, COVID-19 can cause its reactivation, which often manifested by clinic acute hepatitis. The article presents clinical case development hepatitis patient mixed infection EBV ...