Malignant melanoma is a rare disease in Asians but potentially the most aggressive form of skin cancer worldwide. It can occur in any melanocyte-containing anatomic site. Four main cutaneous melanoma subtypes are recognized: lentigo maligna melanoma, superficial spreading melanoma, acral lentiginous melanoma (ALM), and nodular melanoma. Generally, excessive exposure to ultraviolet (UV) radiatio...

In Caenorhabditis elegans, gentle touch is sensed by the anterior (ALM and AVM) and posterior (PLM) touch receptor neurons. Anterior, but not posterior, touch is affected by several stress conditions via the action of AKT kinases and the DAF-16/FOXO transcription factor. Here we show that a ubiquitination-dependent mechanism mediates such effects. AKT-1/AKT kinase and DAF-16 alter the transcrip...

This paper describes a modular action language,ALM, dedicated to the specification of complex dynamic systems. One of the main goals of the language is to facilitate the development and testing of knowledge representation libraries. We present the implementation of a large scale library of commonsense concepts, achieved by porting knowledge from the Component Library (CLIB) into ALM. Our choice...

BACKGROUND A vaccine consisting of a single dose of whole-cell autoclave-killed Leishmania major (ALM) mixed with BCG was assessed in comparison with BCG alone against anthroponotic (human to human transmission) cutaneous leishmaniasis in a randomised double-blind trial in Bam, Iran. METHODS 3637 schoolchildren, aged 6-15 years, with no history of cutaneous leishmaniasis and no response to a ...

In den letzten Jahren kamen verstärkt so genannte „Application Lifecycle Management“ (ALM) Werkzeuge auf den Markt, die den Anspruch haben, die verschiedenen Aktivitäten des Entwicklungsprozesses ineinander verzahnt zu unterstützen. Dieser ganzheitliche Ansatz findet sich ebenso in den agilen Entwicklungsmethoden wieder. Dabei stellt sich die Frage wie ALM Werkzeuge in der Praxis ihrem Anspruch...

In this paper we study the introduction of new assets which are oftenly observed to be de…ned in expected values rather than state by state, called the Arrow-Lind-Malinvaud (ALM) assets. We demonstrate that individual default emerges naturally in an economy where such ALM assets are introduced without completing all contingency markets. We further provide conditions under which individual defau...

The Application Level Multicast (ALM) simplifies the implementation of group communication. However, it still suffer from the same management overhead in case of highly dynamic sessions. In this paper, we propose an efficient key management protocol, called Transition Key Scheme (TKS), for ALM communication. TKS aims to reduce the key management overhead in case of highly dynamic membership ses...

The nuclear norm is widely used to induce low-rank solutions for many optimization problems with matrix variables. Recently, it has been shown that the augmented Lagrangian method (ALM) and the alternating direction method (ADM) are very efficient for many convex programming problems arising from various applications, provided that the resulting subproblems are sufficiently simple to have close...