Skeletal muscle triglyceride accumulation is associated with insulin resistance in obesity. Recently, it has been suggested that alpha lipoic acid (ALA) improves insulin sensitivity by lowering triglyceride accumulation in nonadipose tissues via activation of skeletal muscle AMP-activated protein kinase (AMPK). We examined whether chronic ALA supplementation prevents muscular lipid accumulation...

Background: Myocardial ischemia/reperfusion (I/R) injury is one of the pre-eminent causes death. Prevention I/R in diabetic patients full ups and downs. This study has investigated effect co-administration alpha-lipoic acid (ALA) preconditioning ischemic-postconditioning (Post) on myocardial fibrosis type-II rats suffering from injury. Methods: Chronic diabetes was induced by a high-fat supplem...

Cadmium (Cd) is a well-known human carcinogen and a potent nephrotoxin. The protective effects of alpha-lipoic acid and melatonin against cadmium (Cd) induced oxidative stress to erythrocytes in rats were evaluated. One hundred male albino rats were divided into five groups containing 20 rats each. Group I: (control) administered distilled water. Group II :( Cadmium exposed group) received cadm...

The present study was conducted to determine the effects of L-carnosine (LC) and/or alpha-lipoic acid (ALA) supplementation on growth performance, blood thyroid hormones and lipid profiles in finishing pigs. A total of 40 (Landrace×Yorkshire) pigs with an initial body weight of 57.93±3.14 kg were randomly allocated to 4 experimental diets using a 2×2 factorial arrangement with 2 LC supplemental...

BACKGROUND Amelioration of insulin resistance could improve both glycaemic control and cardiovascular risk factors in patients with type 2 diabetes mellitus. Alpha-lipoic acid has been shown to improve insulin action after parenteral administration. OBJECTIVE the aim of the study was to assess the effect of oral administration of alpha-lipoic acid on insulin sensitivity in patients with type ...

Advanced glycation end products (AGEs) have been identified as relevant mediators of late diabetic complications such as atherosclerotic disease. The endothelial migration of monocytes is one of the first steps in atherogenesis and monocyte-endothelial interaction itself is linked to the expression of adhesion molecules like vascular cell adhesion molecule-1 (VCAM-1). Recently, stimulation of V...

Abstract Background Cytarabine (Ara-C) is an anticancer drug, which considered as the mainstay in treatment of hematological malignancies, known to cause various teratogenic effects. Alpha-lipoic acid (ALA) a natural antioxidant and its supplementation proved improve pregnancy outcomes several pathological conditions. We aimed at exploring benefits maternal ALA against in-utero Ara-C exposure-i...

Alpha-lipoic acid has been found to enhance glucose uptake into skeletal muscle in animal models. Studies have also found that the co-ingestion of carbohydrate along with creatine increases muscle creatine uptake by a process related to insulin-stimulated glucose disposal. The purpose of this study was to determine the effect of alpha-lipoic acid on human skeletal muscle creatine uptake by dire...

OBJECTIVE Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, plays a protective role in the vascular system. HO-1 induction inhibits cytokine production in macrophages. Antioxidants induce HO-1 expression in various cell types. Alpha-lipoic acid (ALA), a thiol-containing dietary antioxidant, exhibits protective effects in vascular disease and induces anti-inflammatory effects...