alzheimer disease

OBJECTIVE To examine change in cognitive function in older persons sampled from a community population, and its relation to age and Alzheimer disease. DESIGN Prospective cohort study with an average of 3.5 years of follow-up. SETTING East Boston, Mass--a geographically defined, urban, working-class community. PARTICIPANTS A stratified, random sample of persons 65 years and older underwent...

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Evidence for a membrane defect in Alzheimer disease brain.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1992

R M Nitsch J K Blusztajn A G Pittas B E Slack J H Growdon R J Wurtman

To determine whether neurodegeneration in Alzheimer disease brain is associated with degradation of structural cell membrane molecules, we measured tissue levels of the major membrane phospholipids and their metabolites in three cortical areas from postmortem brains of Alzheimer disease patients and matched controls. Among phospholipids, there was a significant (P less than 0.05) decrease in ph...

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p 62: markers of neuroinflammation related to alzheimer's disease pathology in the elderly

Journal: :مجله علوم اعصاب شفای خاتم 0

maryam moghadamqaeni student research committee, facuilty of medicine, islamic azad university, mashhad branch, mashhad, iran zahra sheidaemehne student research committee, facuilty of medicine, islamic azad university, mashhad branch, mashhad, iran

alzheimer disease (ad) is a neurodegenerative disorder and the most common form of dementia. increasing evidence suggests that alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. in vitro and animal studies have linked neuroinflammation to alzheimer's disease (ad) pathology. studie...

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