نتایج جستجو برای: alzheimer disease ad
تعداد نتایج: 1556084 فیلتر نتایج به سال:
I. The Alzheimer Disease Puzzle 466 A. The amyloid cascade hypothesis 466 B. Moving towards more comprehensive theories for AD 466 C. The importance of tau 467 II. Proteolysis Involved in Multiple Scenarios for Alzheimer Disease 467 A. Proteolytic processing of the APP 467 B. General disturbances of the endolysosomal-phagocytotic system in AD neurons 468 III. Heterogeneity of the Amyloid A Pept...
Alzheimer's disease (AD) is the most common neurodegenerative disease presenting major health and economic challenges that continue to grow. Mechanisms of disease are poorly understood but significant data point to metabolic defects that might contribute to disease pathogenesis. The Alzheimer Disease Metabolomics Consortium (ADMC) in partnership with Alzheimer Disease Neuroimaging Initiative (A...
As the most common cause of dementia among the elderly results in cognitive and ‎behavioral impairment, Alzheimer’s disease (AD) is characterized with aggregation of senile ‎plaques (Beta-amyloid protein), cortical atrophy and ventricular enlargement. Unfortunately, ‎conventional methods like acetyl cholinesterase inhibitor drugs, are not so effective owing to ‎restrictive...
Increasing interest is being shown in the link between olfaction, a complex sensory system, and cognition, particularly in the elderly. Olfaction is known to affect cognitive abilities and mood. In this article, we consider the impairment of olfactory function due to Alzheimer disease (AD), Parkinson disease (PD) and Lewy body disease (LBD), through pathological changes in the peripheral and ce...
Biochemical markers for Alzheimer disease would be of great value, especially to help in early diagnosis of the disease. The current study has focused on three candidates that have been suggested to be indulged in the pathogenesis of Alzheimer’ disease (AD): Tissue transglutaminase (tTG) activity, β-amyloid42 (Aβ 42) and total T-tau (T-tau). The study included 15 patients with probable AD, 15 p...
Although forms of dementia arising late in life had been identified by Kraepelin and his colleagues in the 1800s, it was not until 1907 that Alois Alzheimer identified the presenile form of dementia with unique neuropathologic features that now bears his name. Alzheimer described a 51year-old woman who presented with personality changes and soon developed progressively worsening memory loss, di...
OBJECTIVE To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD). METHODS The authors assessed the amount of protein carbonyls, thiobarbituric acid-reactive substances (TBARS), and malondialdehyde in the superior and middle temporal gyri (SMTG) and cerebellum of shor...
There is a great benefit of Alzheimer disease (AD) classification for health care application. AD is the most common form of dementia. This paper presents a new methodology of invariant interest point descriptor for Alzheimer disease classification. The descriptor depends on the normalized Hu Moment Invariants (NHMI). The proposed approach deals with raw Magnetic Resonance Imaging (MRI) of Alzh...
Alzheimer disease (AD) is characterized by deposition of amyloid-beta, tau, and other specific proteins that accumulate in the brain in detergent-insoluble complexes. Alzheimer disease also involves glutamatergic neurotransmitter system disturbances. Excitatory amino acid transporter 2 (EAAT2) is the dominant glutamate transporter in cerebral cortex and hippocampus. We investigated whether accu...
introduction: olibanum improves memory in different models of learning. however, the effect of olibanum on models of alzheimer’s disease has been less studied. in the present study, the effect of olibanum on memory in normal rats and in a rat model of alzheimer disease induced by intracerebroventricular injections of streptozotocin was evaluated. methods: rats received an aqueous extract of oli...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید