Results from our group showed benzyl salicylate to be a moderate inhibitor of the CD81-LEL-HCV-E2 interaction. To increase the biological activity, heterocyclic substituted benzoic acids were coupled to amino acid esters via microwave assisted DCC-reaction. The prepared compounds were tested for their inhibitory potency by means of a fluorescence labeled antibody assay system using HUH7.5 cells.

The compound Pyrazole derivatives, is prepared from p – Amino benzoic acid and ethanol. Chalcone has been prepared by the condensation reaction of Ethyl-4-acetamido benzoate and different ten aldehydes. These chalcones are cyclized with hydrazine hydrate and glacial acetic acid under reflux condition give pyrazole derivatives. These compounds have been characterized by detailed spectral analysi...

OxymaPure (ethyl 2-cyano-2-(hydroxyimino)acetate) was tested as an additive for use in the carbodiimide (DIC) approach for the synthesis of a novel series of α-ketoamide derivatives (4-[2-(2-acetylaminophenyl)-2-oxo-acetylamino]benzoyl amino acid ester derivatives). OxymaPure showed clear superiority to HOBt/DIC or carbodiimide alone in terms of purity and yield. The title compounds were synthe...

In the current work, azo ligand and its Pd (Ⅱ), Cd Zn (Ⅱ) Hg complexes were synthesized, characterized their spectroscopic characteristics studied. The new was synthesized from coupling reaction between 4,5-bis(4-methoxy phenyl)imidazole diazonium salt of 4-Amino benzoic acid in an alkaline medium at 0-5 ᵒC. metal prepared by metals chlorides. All compounds FT-IR, 1H-NMR, Mass spectral analysis...

1. The extent to which phenolic derivatives of benzoic acid (seven); of phenylacetic acid (one); of 3-phenylpropionic acid (one) and of cinnamic acid (six) served as precursors of the urinary benzoic acid excreted by sheep was determined after administration as continuous drips via rumen or abomasal cannulas. 2. Phenolic derivatives of benzoic or of phenylacetic acid were not dehydroxylated to ...

Penicillin acylase catalyses the hydrolysis and synthesis of semisynthetic beta-lactam antibiotics via formation of a covalent acyl-enzyme intermediate. The kinetic and mechanistic aspects of these reactions were studied. Stopped-flow experiments with the penicillin and ampicillin analogues 2-nitro-5-phenylacetoxy-benzoic acid (NIPAOB) and d-2-nitro-5-[(phenylglycyl)amino]-benzoic acid (NIPGB) ...

3, 5-Cyclohexadiene1, 2-diol1-carboxylic acid (1, 2-dihydro1, 2-dihydroxybenzoic acid) is converted enzymatically to catechol in cell extracts from Acinetobacter, Alcaligenes, Azotobacter, and three Pseudomonas species. This enzymatic activity is present only in cultures which have been grown in the presence of benzoic acid, and which convert benzoic acid to catechol rather than to protocatechu...

A new heterocyclic Schiff base ligands and their complexes have been synthesized from 4-aminoantipyrine, thiophene-2-Carboxaldehyde and 2-amino benzoic acid. The ligands and its transition metal complexes of Cu (II), Co (II), Ni (II) and Zn (II) are characterized by UV, FTIR NMR and Mass studies. The antibacterial and antifungal activity of the ligands and the metal complexes were tested.