Kisspeptin is the product of the KISS1 (KiSS-1 metastasissuppressor) gene and is the ligand for the G-protein– coupled receptor, now known as the KISS1 receptor (KISS1R) (1 ). Both kisspeptin and KISS1R play a crucial role in the regulation of reproduction and puberty (1 ). The KISS1 gene encodes a precursor peptide of 145 amino acid residues, which undergoes proteolytic processing to generate ...

Potential limitations of prenatal diagnosis of hemophilia B, as compared to hemophilia A, include (1) occurrence of far more frequent defects with abnormal circulating antigen, (2) lower levels of factor IX in fetal plasma at 16 to 20 weeks gestation, and (3) the presence of factor IX antigen in amniotic fluid. In addition, proteolysis could occur, especially with amniotic fluid contamination o...

background: the aim of this study was to compare the biophysical profile parameters (bpp), especially amniotic fluid index (afi), before and after administration of corticosteroids (dexamethasone and betamethasone) and these two groups with each other. materials and methods: this double-blind clinical trial study was done on 70 patients for 28–34 weeks women having at least one preterm labor in...

results afscs have the potential to be used in tissue repair and regeneration of bladder and kidney injuries, for the treatment of congenital anomalies like tracheal anomalies and spina bifida therapy etc. however, like other treatment, afscs also have some limitations such as low rate of differentiation of transplanted afscs and immune rejection. conclusions afscs have great therapeutic potent...

A glycoprotein immunologically related to plasma cold-insoluble globulin (CIG) and fetal skin fibroblast fibronectin has been purified from second-trimester human amniotic fluid. This protein (amniotic fluid fibronectin) migrated more slowly than CIG on sodium dodecyl sulfate gel electrophoresis and showed greater polydispersity which could result, at least in part, from heterogeneity in glycos...

OBJECTIVE To investigate methionine metabolism during normal human embryonic development by measuring levels of methionine and total homocysteine in samples of maternal serum, extra-embryonic coelomic fluid, and amniotic fluid. DESIGN Cross-sectional observational study. SETTING Collaboration between St Bartholomew's Hospital, London, and the University Hospital of Nijmegen in The Netherlan...

OBJECTIVE Prenatal androgen exposure has been suggested to play a role in polycystic ovary syndrome. Given the limited information on what maternal characteristics influence maternal testosterone levels, and the even less explored routes by which female fetus androgen exposure would occur, the aim of this study was to investigate the impact of maternal age, BMI, weight gain, depressed mood and ...

OBJECTIVE The high risk of nonunion represents a challenge in vertebral surgery, thus stimulating new strategies to improve fusion rates. We investigated the effect of 2 different bone grafts and amniotic fluid application on radiologically and histologically evaluated vertebral fusion in an experimental rat model. MATERIALS AND METHODS Forty-eight 24-week-old Sprague Dawley rats were include...

Injection of amniotic fluid stem cells ameliorates the acute phase of acute tubular necrosis in animals by promoting proliferation of injured tubular cells and decreasing apoptosis, but whether these stem cells could be of benefit in CKD is unknown. Here, we used a mouse model of Alport syndrome, Col4a5(-/-) mice, to determine whether amniotic fluid stem cells could modify the course of progres...

BACKGROUND Ultrasound assessment of amniotic fluid has important implication in obstetrics care and it has become an integral and important component of pregnancy assessment. Changes in amniotic fluid volume are associated with adverse outcome. Excess volume is associated with foetal anomalies and aneuploidy and less volume is associated with Intra Uterine Growth Retardation, renal anomalies in...