In prospect of developing an oral dosage form of Infliximab, for treatment of Crohn's disease and rheumatoid arthritis, freeze-drying (vial vs Lyoguard trays) and spray-drying were investigated as production method for stable powders. Dextran and inulin were used in combination with sucrose as stabilizing excipients. The drying processes did not affect Infliximab in these formulations, i.e. bot...

Spray freeze drying was developed to produce dry powders suitable for applications such as inhalation delivery. In the current study, the spray freeze drying technique was employed to produce inhalable salmon calcitonin microparticles. Effects of the carrier type, concentration of hydroxyl propyl-β-cyclodextrin and the presence of Tween 80 on the chemical and structural stability, as well as on...

In our daily lives we assist to an exponential growth of mobile and fixed devices that surround us, though many of them having limited resources, and not even providing an interface screen. In this paper, we present remoteU¡, a middleware that allows the interaction of those devices with users, resorting to simple but expressive programming mechanisms, and providing efficient implementation and...

BACKGROUND The intention of this research was to prepare and compare various solubility-enhancing nanoparticulated systems in order to select a nanoparticulated formulation with the most improved oral bioavailability of poorly water-soluble fenofibrate. METHODS The most appropriate excipients for different nanoparticulated preparations were selected by determining the drug solubility in 1% (w...

abstract                                                                               the new drug delivery systems have been developed, which can remain in the stomach for prolonged period of time. the effervescent floating tablet is one of these systems. iron deficiency anaemia is a common disease in the world. ferrous sulphate is the most common ferrous preparation used to treat and prevent...