Our studies examined the role of dopamine D4 receptors in the induction of behavioral sensitization to amphetamine (Amp) and accompanying neurochemical and molecular adaptive responses using a highly selective D4 antagonist, PNU-101387G. Behavioral sensitization to an acute challenge of Amp (2 mg/kg, s.c.) was observed in rats pretreated with five daily doses of Amp (2 mg/kg/d, s.c.) followed b...

Abstract. In this paper, complex network theory has been applied to reveal the transport patterns and cooperative regions of fine particulate matter (PM2.5) over China from 2015 2019. The results show that degrees, weighted edge lengths PM2.5 cities follow power law distributions. We find in Beijing–Tianjin–Hebei–Henan–Shandong (BTHHS) region have a strong ability export pollution other cities....

BACKGROUND There is a need for data on the clinical safety of anthroposophic medicinal products (AMPs). OBJECTIVES The main objective of this analysis was to determine the frequency of adverse drug reactions (ADRs) to AMPs, relative to the number of AMP prescriptions. METHODS EvaMed (Evaluation of Anthroposophic Medicine) was a prospective pharmacovigilance study with the patients of 38 phy...

The D-AMP methodology, recently proposed by Metzler, Maleki, and Baraniuk, allows one to plug in sophisticated denoisers like BM3D into the AMP algorithm to achieve state-of-the-art compressive image recovery. But AMP diverges with small deviations from the i.i.d.-Gaussian assumption on the measurement matrix. Recently, the VAMP algorithm has been proposed to fix this problem. In this work, we ...

DNA gyrase, a type II topoisomerase, regulates DNA topology by creating a double-stranded break in one DNA duplex and transporting another DNA duplex [T-DNA (transported DNA)] through this break. The ATPase domains dimerize, in the presence of ATP, to trap the T-DNA segment. Hydrolysis of only one of the two ATPs, and release of the resulting Pi, is rate-limiting in DNA strand passage. A long u...

In vitro enzyme-based ATP regeneration systems are important for improving yields of ATP-dependent enzymatic reactions for preparative organic synthesis and biocatalysis. Several enzymatic ATP regeneration systems have been described but have some disadvantages. We report here on the use of polyphosphate:AMP phosphotransferase (PPT) from Acinetobacter johnsonii strain 210A in an ATP regeneratio...

This thesis broadens the space of rich yet practical models for structured prediction. Weintroduce a general framework for modeling with four ingredients: (1) latent variables,(2) structural constraints, (3) learned (neural) feature representations of the inputs, and(4) training that takes the approximations made during inference into account. The thesisbuilds up to this framewo...

igraine has generally been conceptualized as a primary isorder of the brainstem that mediates sensory input and eural influences on cranial vessels. It is estimated that ,500,000 patients in the U.S. have at least one migraine per eek, with a lifetime prevalence of 18%. Migraine is a risk actor for cryptogenic stroke, particularly in young patients ithout atherosclerosis risk factors. In fact, ...

A series of novel benzimidazole derivatives 3-10 were synthesized. Benzimidazolyl-substituted acrylonitriles 3 and 4 underwent a photochemical dehydrocyclization reaction to give the corresponding mono- and dicyano-substituted benzimidazo[1,2-a] quinolines 5 and 6. Pinner reaction of these compounds did not give the expected mono- and diamidines, but rather only compounds 7-10, with amido group...