Alpha-amylase is widely used as an industrial enzyme, and a therapeutic target for which inhibitors are designed. Organic solvents are used to dissolve various compounds that would be studied as moderators of alpha-amylases, but they could themselves affect enzyme activity and stability. Methanol, ethanol and propanol are simple alcohols that may be commonly used to this end, and their effect h...

The -amylase inhibitors have been purified and characterized from several plant species. Six classes of -amylase inhibitors have been classified by their structures. They play important roles in the control of endogenous amylases as well as the protection against pathogens and pests. The purification methods, classification, function, inhibition mechanism together with their applications in agr...

Liquiritigenin is a chiral flavonoid present in plant based food, nutraceuticals, and traditional medicines. It is also an important ingredient present in licorice. The purpose of this study is to explore the pharmacological activity of racemic liquiritigenin utilizing several in vitro assays with relevant roles in colon cancer and diabetes. Where possible, the pure enantiomers were tested to i...

Materials and Methods: Antidiabetic potential of GW was evaluated by assay of α-amylase and α-glucosidase inhibitory activity; haemoglobin glycosylation and yeast glucose uptake. The antioxidant potential of GW was assessed by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay, 2,2′azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation decolorization assay and superoxide assay. The inh...

1. Abdin, M., Hamed, Y.S., Akhtar, H.M.S., Chen, D., Mukhtar, S., Wan, P., Riaz, A., Zeng, X. (2019). Extraction optimisation, antioxidant activity and inhibition on ?-amylase pancreatic lipase of polyphenols from the seeds Syzygium cumini. International Journal Food Science Technology, 54(6), 2084-2093. https://doi.org/10.1111/ijfs.1.... CrossRef Google Scholar

In the current investigation, 474 endophytic fungi were isolated from 1200 plant parts of four species Indian traditional medicinal Salacia collected in different seasons. Among them, Fusarium oxysporum, Penicillium notatum, Pestalotiopsis sps and Phoma as a dominant genus S. chinensis, oblonga, fruticosa macrosperma respectively. Most isolates have shown potential anti-diabetic activity throug...

The effects of three calmodulin antagonists on rat parotid amylase release were investigated in vitro using a dispersed acinar cell preparation. The potent calmodulin antagonists, trifluoperazine (TFP) and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), inhibited both 1 microM isoproterenol (ISO)- and 1 mM dibutyryl cyclic AMP (DBcAMP)-stimulated amylase release in a dose-dependent ma...