Protein aggregation is phenomenon wherein protein loses its native structure and aggregates due to the adaption of non-native conformation. Amyloid aggregation formed by the accumulation of various proteins causes many diseases in humans and other organisms. Antioxidants can prevent proteins aggregation. Pulicaria undulata  extract along with phenolic compounds can increase protein stability an...

this study describes the organic synthesis of 5-(2-amimo-4-styryl pyrimidine-4-yl)-4-methoxy benzofuran-6-ol (spbf) as an example of a benzofuran derivative used as a new series of amyloid imaging agents. these benzofuran derivatives may be useful amyloid imaging agents for detecting b-amyloid plagues in the brain of alzheimer’s disease. the precursor is 1-[6-hydroxy-4-methoxybenzofuran-5-yl]-p...

Progressive cognitive decline is one of the hallmark symptoms of Alzheimer’s disease (AD) which can be modeled by β-amyloid injection into specific regions of brain. Since epigallocatechin-3-gallate (EGCG) is a potent antioxidant agent which its role against oxidative stress and inflammation has been shown in prior studies, we tried to determine whether EGCG administration protects against β-am...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 cerebral amyloid angiopathy (caa) is the most common cause of lobar intracerebral hemorrhage. repeated bleeding may be presented with vascular dementia. we have reported a 68-year-old normotensive demented patient with probable caa presented with hemiparesia, headache and vomiting. according to the experience of this case,...

  Abstract   Introduction: Neurodegeneration change is one of the hallmark symptoms of which Alzheimer’s disease (AD) can be modeled by β-amyloid injection into specific regions of brain. (-)-Epigallocatechin-3-gallate (EGCG) is a potent antioxidant agent that its role against oxidative stress and inflammation has been shown in prior studies. In the present study, we have wanted to determine wh...

platelet aggregation beta amyloid main causes inflammation of neurons in alzheimer’s disease. in fact, creating this inflammation due to inappropriate actions in blood brain barrier (bbb) and astrocyte and microglia during the last century that studies conducted in this case nothing has been found. the only thing that can be done to prevent and reduce pro-inflammatory factors such as cytokines ...

the aberrant assembly of proteins into fibrillar aggregates is accused to be the primary cause of pathogenesis of neurodegenerative diseases. but the structural determinants of protein fibrils that are responsible for cell dysfunction are not yet clear. in the current study, cell culture, spectroscopic techniques as well as theoretical and structural investigations were used to determine the ab...

background: alzheimer’s disease (ad) is a neurodegenerative disorder with progressive loss of cognitive abilities and memory loss. the aim of this study was to compare neuropathological changes in hippocampus and brain cortex in a rat model of ad. methods: adult male albino wistar rats (weighing 250-300 g) were used for behavioral and histopathological studies. the rats were randomly assigned t...