Injections of heparin had no effect on the dextran anaphylactoid reaction in rats but neutralised the inhibitory action both of protamine and of borate. Heparin, protamine, and borate did not modify the histamine or 5-hydroxytryptamine responses in rat paws and so their effects on dextran may be due to modification of the release mechanisms of these two amines from tissue mast cells. Correspond...

Antoantibodies to cholesterol were detected and purified from normal (nonimmunized) pig serum. The antibodies were assayed by ELISA with crystalline cholesterol as an Ag and by C-dependent damage to cholesterol-laden liposomes. Intravenous injection of liposomes containing cholesterol into anesthetized animals caused decreased hemolytic complement titers, and induced a reaction consisting of tr...

This brief monograph is an excellent review of the extra-articular manifestations of rheumatoid arthritis from the standpoint of diagnosis, therapy and relationship to the overall features of the disease. Most of the material comes from published reports and reviews in individual areas, embellished by Dr. Hollingsworth's personal experience while he was Chief of Rheumatology at the Yale Univers...

Previous studies highlighted the anaphylactoid nature of liposome reactions, pointing to activation of the complement (C) system as probably the underlying cause [13]. It was also established earlier that multilamellarity, large size, and the presence of very high amounts of cholesterol in the bilayer membrane are likely one of the main cause of C activation and anaphylactoid reactions. More re...

A patient with apparent X-linked agammaglobulinaemia was found to be inordinately susceptible to anaphylactoid reactions to intramuscular injections of gammaglobulin. The patient was found also to have low levels of C1 esterase inhibitor (C1 INH). The possibility that the C1 INH deficiency and in this patient, whether genetic or acquired, fostered the susceptibility to the production of anaphyl...

Introduction: Shuanghuanglian injection (lyophilized) (SHLI) is commonly used to treat respiratory tract infection. Shenmai (SMI) mainly cardiovascular diseases. Despite their widespread clinical use, anaphylactoid reactions (ARs) induced by SHLI and SMI have been reported, which attracted broad attention. However, the impact of ARs on metabolic changes underlying mechanisms are still unclear. ...