Maturation in hooded seals is characterized by the rapid development of their physiological diving capacity and is accompanied by increases in oxidant production but not oxidative damage. To test the hypothesis that the antioxidant system of hooded seals develops as they transition from a terrestrial to an aquatic environment, we obtained the complete cDNA sequence that encodes the NF-E2-relate...

We have used a cloned cDNA for the major human selenoprotein, glutathione peroxidase (GPx), to assess the mode of regulation of human GPx gene (GPX-1) expression by selenium. When the HL-60 human myeloid cell line is grown in a selenium-deficient medium, GPx enzymatic activity decreases 30-fold compared with selenium-replete cells. Upon return to a medium containing selenium in the form of sele...

Among major reactive oxygen species (ROS), hydrogen peroxide (H2O2) exhibits dual roles in plant metabolism. Low levels of H2O2 modulate many biological/physiological processes in plants; whereas, its high level can cause damage to cell structures, having severe consequences. Thus, steady-state level of cellular H2O2 must be tightly regulated. Glutathione peroxidases (GPX) and ascorbate peroxid...

Kunwar A, Haston CK. Basal levels of glutathione peroxidase correlate with onset of radiation induced lung disease in inbred mouse strains. Am J Physiol Lung Cell Mol Physiol 307: L597–L604, 2014. First published August 22, 2014; doi:10.1152/ajplung.00088.2014.— Biomarkers predicting for the radiation-induced lung responses of pneumonitis or fibrosis are largely unknown. Herein we investigated ...

It has been accepted that for most species newborns and senescent organisms are more sensitive than other ages to environmental stressors. Nevertheless, it must be considered that there are several biochemical and physiological compensatory processes which are not expressed with the same magnitude during the whole life cycle. With this aim, Daphnia magna individuals of different age were expose...

background: the aim of this study was to evaluate the possible protective effect of sodium selenite on serum, liver, and kidney antioxidant enzymes activities in alloxan-induced type 1 diabetic rats. methods: forty sprague-dawley male rats were randomly divided into four groups; group one as control, group two as sham-treated with sodium selenite by 1 mg/kg intraperitoneal (i.p.) injections dai...

UNLABELLED Prostate adenocarcinoma (PC) and benign prostate hyperplasia (BPH) are age-related diseases. The augmented oxidative stress is suggested to play an important role in the pathogenesis of both mentioned prostate disorders. In the presented study the antioxidant defense system in PC and BPH patients has been evaluated. The study was carried out on 30 PC patients (age 61±8 years) and 30 ...

Altered antioxidant status has been reported in schizophrenia. The glutathione (GSH) redox system is important for reducing oxidative stress. GSH, a radical scavenger, is converted to oxidized glutathione (GSSG) through glutathione peroxidase (GPx), and converted back to GSH by glutathione reductase (GR). Measurements of GSH, GSSG and its related enzymatic reactions are thus important for evalu...

Manganese-containing superoxide dismutase (MnSOD) is an essential primary antioxidant enzyme that converts superoxide radical to hydrogen peroxide and molecular oxygen within the mitochondrial matrix. Cytosolic glutathione peroxidase (GPX) converts hydrogen peroxide into water. MnSOD is reduced in a variety of tumor types and has been proposed to be a new kind of tumor suppressor gene, but the ...