CADTH recommends that Pluvicto should be reimbursed by public drug plans for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) if certain conditions are met.
 only covered to treat prostate-specific membrane antigen (PSMA)-positive mCRPC who have received previous at least 1 androgen receptor pathway inhibitor (ARPI) and taxane-containing regimen...

The development of polycystic ovary syndrome (PCOS) is closely related to the chronic inflammatory and obese. Recent studies have found macrophages regulate inflammation adipose tissue remodelling, but underlying mechanisms not been clarified. In this study, we established a model PCOS in offspring rats by high androgen exposure during late pregnancy parental female rat macrophage eliminating r...

This paper is designed to give an overview of the mechanism of androgen action and some of the factors that can affect it. The discussion of androgen action includes androgen transport in the blood, metabolism, receptor binding, nuclear activation and selected aspects of biological response. The importance of recognizing interspecies and interstrain differences in specific aspects of androgen a...

This review presents the androgen receptor gene and its clinical importance in gynecology, oncology and infertility. A computerized literature search through Medline and PubMED was performed, applying the word " androgen receptor " cited between the years 1990 and 2009. The androgen receptor mediates androgen action, determining male sexual phenotypes and spermatogenesis. Constitutional mutatio...

Androgen ablation is the primary treatment modality for patients with metastatic prostate cancer; however, the role of androgen receptor signaling in prostate cancer development remains enigmatic. Using a series of genetically defined immortalized and tumorigenic human prostate epithelial cells, we found that introduction of the androgen receptor induced differentiation of transformed prostate ...

PURPOSE Androgen ablation therapy leads to mild regression or stabilization of prostate cancer, followed by progression to the fatal androgen-independent state. Whereas androgen ablation diminishes tumor angiogenesis by suppressing vascular endothelial growth factor (VEGF) production, androgen-independent disease is marked by androgen-independent VEGF expression. We examined combined androgen a...

The androgen receptor (AR) is a critical effector of prostate cancer development and progression. Androgendependent prostate cancer is reliant on the function of AR for growth and progression. Most castration-resistant prostate cancer (CRPC) remains dependent on AR signaling for survival and growth. Ribosomal RNA (rRNA) is essential for both androgen-dependent and castration-resistant growth of...

BACKGROUND Androgen withdrawal in normal prostate or androgen-dependent prostate cancer is associated with the downregulation of several glycolytic enzymes and with reduced glucose uptake. Although glycogen metabolism is known to regulate the intracellular glucose level its involvement in androgen response has not been studied. METHODS We investigated the effects of androgen on glycogen phosp...

The androgen receptor is an androgen-dependent transcription factor that belongs to the nuclear superfamily. When not bound its ligand, it mainly localized in cytoplasm, chaperone proteins, which stabilizes inactive conformation and confers a high affinity for ligand. conformational change of begins when molecule binds receptor, subsequently homodimerizes actively translocated nucleus. In nucle...

The motoneurons of the spinal nucleus of the bulbocavernosus (SNB) and its target muscles, the bulbocavernosus and levator ani, form a sexually dimorphic circuit that is developmentally dependent on androgen exposure and exhibits numerous structural and functional changes in response to androgen exposure in adulthood. Castration of male adult rats causes shrinkage of SNB somata, and testosteron...