نتایج جستجو برای: androstenedione
تعداد نتایج: 1536 فیلتر نتایج به سال:
In order to study the initial as well as the final steps in the aromatization of androgens to estrogens, highspecific activity [ 19-CSHs]androstenedione and testosterone were synthesized. Incubations of [ 19-CSHs]androstenedione with human placental microsomes resulted in the generation of [‘Hlwater, as a result of the dual hydroxylation at (2-19, and [’Hlformic acid reflecting final aromatizat...
The mare is the only non-primate species known to display estrous signs after ovariectomy and adrenal hormones have been implicated as a possible cause. Moreover, in several species, estradiol seems to have a stimulatory effect on the hypothalamic-pituitary-adrenal axis. The aim of the present study was to compare the effect of ACTH (tetracosactide) on pertinent hormones [cortisol, progesterone...
BACKGROUND Hyperandrogenic conditions have been associated with a high prevalence of endometrial pathologies related to cell survival. However, the action of androgens on proliferation and apoptosis in endometrial cells is poorly understood. Therefore, the aim of the present study was to evaluate the effect of androstenedione on cell proliferation, cell death and expression of estrogen receptor...
BACKGROUND The human breast contains all the enzymes responsible for local bioformation of estradiol (E2). Two principal pathways are implicated in the last steps of E2 formation: the 'aromatase' which transforms androgens into estrogens, and the 'sulfatase' which converts estrogen sulfates into active unconjugated estrogens; activities found in both normal and cancerous breast. Aromatase inhib...
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