objective(s): progestrone is a prequisite for pre-implantation angiogenesis and induce decidual angiogenesis. it is unknown the effect of progestrone administration on the endometrium of hyperstimulated mice at pre-implantation time. material and methods: adult female nmri mice were divided in three groups [control group, ovarian stimulated group and progestrone treated mice after ovarian stimu...

Tumor necrosis-factor-related apoptosis-inducing ligand (TRAIL) has been implicated in angiogenesis; the growth of new blood vessels from an existing vessel bed. Our aim was to compare pro-angiogenic responses of TRAIL, vascular endothelial growth-factor-A (VEGF-A) and fibroblast growth-factor-2 (FGF-2) either separately (10 ng/mL) or in combination, followed by the assessment of proliferation,...

BACKGROUND Vascular modifications occur early in the development of psoriasis, and angiogenesis is one of the key features in the pathogenesis of the disease. OBJECTIVES To identify the role of the S100 protein psoriasin in psoriasis-associated angiogenesis. METHODS The role of psoriasin in mediating angiogenesis was investigated by silencing psoriasin with small interfering RNA (siRNA) and...

Angiogenesis plays a very important role in tumor progression through the creation of new blood vessels. Therefore, angiogenesis inhibitors could contribute to cancer treatment. Here, we show that a microbial metabolite, elaiophylin, exhibits potent antiangiogenic activity from in vitro and in vivo angiogenesis assays. Elaiophylin dramatically suppressed in vitro angiogenic characteristics such...

Angiogenesis, new capillary blood vessel formation, is essential for embryonic development, wound healing, and cancer growth. Vascular endothelial growth factor (VEGF) induces angiogenesis by activating endothelial cell migration and proliferation. Serum response factor (SRF) is a transcription factor important for embryonic development and activation of immediate early gene expression. The rol...

Angiogenesis is the formation of new capillaries from pre-existing blood vessels and participates in proper vasculature development. In pathological conditions such as cancer, abnormal angiogenesis takes place. Angiogenesis is primarily carried out by endothelial cells, the innermost layer of blood vessels. The vascular endothelial growth factor-A (VEGF-A) and its receptor-2 (VEGFR-2) trigger m...

Anti-angiogenesis is the therapeutic strategy designed to disrupt vascular supply and starve tumors of nutrients oxygen. This achieved mainly by blocking endothelial growth factor (VEGF) actions, as VEGF signaling pathway considered main angiogenesis promoter active in tumor microenvironment (TME) under hypoxic conditions. A total 16 anti-angiogenic agents, including anti-VEGF antibodies, recep...

Background: Peripheral arterial disease (PAD) can severely compromise limb vitality and function. Angiogenesis plays an important role in healing of ischemic lesions. Radiolabeled RGD (Arg-Gly-Asp) peptides specifically targeting αvβ3 integrin are promising tracers for imaging angiogenesis. In this study, we investigated the application a one-step labeled evaluation angiogenesis therapy respons...