vascular endothelial growth factor (vegf-a) is one of the most important regulatory factors in pathological and physiological angiogenesis. alternative splicing is a complicated molecular process in vegf-a gene expression which adds complexity to vegf-a biology. among all vegf-a exons, alternative splicing of exon 8 is the key determinant of isoform switching from pro-angiogenic vegf-xxx to ant...

In osteoarthritis angiogenesis is involved in the reinitiation of cartilage growth and mineralisation. A number of heparin binding protein growth factors have been proposed as angiogenic factors, but none of them is specific for microvessel cells. Another factor which is specific for microvessel cells, is of low molecular weight and non-profit has been called endothelial cell stimulating angiog...

OBJECTIVE To determine the role of angiogenesis in the clinical behavior and pathogenesis of lymphangioma tumors. DESIGN A retrospective study. Median follow-up period was 44.5 months. SETTING Children's Memorial Hospital, Chicago, Ill. PATIENTS Tumor specimens from 12 pediatric patients who underwent surgical excision of cervicofacial lymphangioma were examined for expression of angiogen...

Angiogenesis is important for wound healing, tumor growth, and metastasis. Endothelial cells differentiate into capillary-like structures on a laminin1-rich matrix (Matrigel). We previously identified 20 angiogenic sites on laminin-1 (a1b1g1) by screening 559 overlapping synthetic peptides. C16, the most potent g1 chain peptide, blocked laminin-1-mediated adhesion and was the only g1 chain pept...