INTRODUCTION The results of large clinical studies indicate that angiotensin-converting enzyme (ACE) inhibitors are effective agents in patients with coronary artery disease (CAD), even if their blood pressure is within normal limits. MATERIAL AND METHODS In the present study, we compared the effect of plasma- and tissue-type angiotensin-converting enzyme inhibitors on plasma levels of leptin...

OBJECTIVES This study sought to assess the effect of angiotensin-converting enzyme (ACE) inhibitors and beta-blockers on all-cause mortality in patients with left ventricular (LV) systolic dysfunction according to gender, race, and the presence of diabetes. BACKGROUND Major randomized clinical trials have established that ACE inhibitors and beta-blockers have life-saving benefits in patients ...

Angiotensin-converting enzyme (ACE) inhibitors reduce the risk of recurrent myocardial infarction in patients with left ventricular dysfunction. Tissue factor (TF), the initiator of blood coagulation, plays a pivotal role in arterial thrombosis that occurs after atherosclerotic plaque fissuring. Because monocytes synthesize TF and contain several components of the renin-angiotensin system, we i...

Angiotensin-converting enzyme 2 (ACE2) shares some homology with angiotensin-converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the degradation of Ang II resulting in the formation of angiotensin 1-7 (Ang 1-7) which opposes the actions of Ang II. Increased Ang II levels are thought to upregulate ACE2 activity, and in ACE2 deficient mice Ang II levels are ap...

QUESTION I read in a Motherisk Update that angiotensin-converting enzyme (ACE) inhibitors are contraindicated during pregnancy. Many women, however, do not know they are pregnant for quite some time after conception. One of my patients was taking ACE inhibitors for 3 to 4 months while she was pregnant. How should I advise her? ANSWER The deleterious effects ACE inhibitors have on fetuses were...

Abstract Background Midkine is a multi-functional molecule participating in various key pathological process. We aimed to evaluate the change of midkine sepsis and its association with angiotensin-converting enzyme (ACE) system, as well mechanism by which induced lung injury. Methods The peripheral blood sample septic patients on admission was obtained measured for midkine, ACE angiotensin II. ...

The COVID-19 pandemic has reached over 100 million worldwide. Due to the multi-targeted nature of virus, it is clear that drugs providing anti-COVID-19 effects need be developed at an accelerated rate, and a combinatorial approach may stand more successful than single drug therapy. Among several targets pathways are under investigation, renin-angiotensin system (RAS) specifically angiotensin-co...

INTRODUCTION It has been suggested that adipose tissue hormones are involved in the mechanism of action of angiotensin-converting enzyme (ACE) inhibitors. Very little is known as to whether the action on resistin contributes to the clinical effectiveness associated with the use of these agents. MATERIAL AND METHODS The aim of this study was to compare the effects of plasma- and tissue-type AC...

Angiotensin-converting enzyme (ACE) is an important zinc-dependent hydrolase responsible for converting the inactive angiotensin I to the vasoconstrictor angiotensin II and for inactivating the vasodilator bradykinin. However, the substrate binding mode of ACE has not been completely understood. In this work, we propose a model for an ACE Michaelis complex based on two known X-ray structures of...

ctivation of the renin – angiotensin system (RAS) has a profound effect on the prognosis of patients with myocardial infarction and/or heart failure with reduced ejection fraction (HFREF), as proven by the beneficial effects of angiotensin-converting enzyme inhibitors (ACEIs).1 Because angiotensin II is produced in the ACE-dependent and -independent pathways,2 the addition of AT1 receptor block...