N-methyl bromide of lidocaine (QX-314) is a potential local anaesthetic with compromised penetration through cell membranes due to its obligated positive charge. Liposomes have been widely used for drug delivery with promising efficacy and safety. Therefore we investigated the local anaesthetic effects and tissue reactions of QX-314 in combination with anionic, cationic or neutral liposomes in ...

Channel-forming colicins are bacterial toxins that spontaneously insert into the inner cell membrane of sensitive bacteria to form voltage-gated ion channels. It has been shown that the channel current and the conformational flexibility of colicin E1 channel domain depend on the membrane surface potential, which is regulated by the anionic lipid content and the ion concentration. To better unde...

Human liver glutathione S-transferases (GSH S-transferases) were fractionated into cationic and anionic proteins. During fractionation with (NH4)2SO4 the anionic GSH S-transferases are concentrated in the 65%-saturated-(NH4)2SO4 fraction, whereas the cationic GSH S-transferases separate in the 80%-saturated-(NH4)2SO4 fraction. From the 65%-saturated-(NH4)2SO4 fraction two new anionic GSH S-tran...

Nisin is a cationic polycyclic bacteriocin secreted by some lactic acid bacteria. Nisin has previously been shown to permeabilize liposomes. The interaction of nisin was analyzed with liposomes prepared of the zwitterionic phosphatidylcholine (PC) and the anionic phosphatidylglycerol (PG). Nisin induces the release of 6-carboxyfluorescein and other small anionic fluorescent dyes from PC liposom...

The Min proteins (MinC, MinD, and MinE) form a pole-to-pole oscillator that controls the spatial assembly of the division machinery in Escherichia coli cells. Previous studies identified that interactions of MinD with phospholipids positioned the Min machinery at the membrane. We extend these studies by measuring the affinity, kinetics, and ATPase activity of E. coli MinD, MinE, and MinDE bindi...

While azolate anions have been extensively used as anionic linkers in framework design, we now demonstrate the synthesis of square-grid networks that utilise their cationic analogues, imidazolium ions, as linkers. The resulting imidazolium frameworks are direct hydrogen-bonded analogues of square-grid metal azolates and the first examples of an inverted polarity framework design based on anioni...

Pediocin PA-1 bound to anionic lipid vesicles with saturated or unsaturated fatty acid chains in a lipid concentration-dependent fashion. Little change in binding parameters was observed for zwitterionic lipid vesicles. Decreasing the anionic lipid content of the vesicles gave a higher relative dissociation constant for the peptide-lipid interactions and further supports the electrostatic inter...

The hetero-anionic lead-free double perovskite halides are realized through mechanochemical synthesis by Tae Heon Kim and co-workers in article number 2201119. degree of anion substitution is tunable inducing manipulation the band gaps emitted colors anionic-mixed halides. gap engineering via exchange applicable to fabricate optoelectronic devices with high performance.

Pulp fibers have a strong tendency to form flocs in water suspensions, which may cause their undesirable distribution in the paper sheets. This flocculation can be controlled by adding, e.g., an anionic high molecular weight polyelectrolyte in the fiber suspension. The objective of this study was to investigate the effect of anionic polyelectrolytes on deflocculation kinetics, dewatering, and r...