OBJECTIVE Nitric oxide is produced by endothelial nitric oxide synthase, and its production can be influenced by polymorphisms of the endothelial nitric oxide synthase gene. Because candidate genes responsible for susceptibility to ankylosing spondylitis are mostly unknown and available data suggest that there may be problems related to the nitric oxide pathway, such as endothelial dysfunction ...

Aims: The objective of the present study was to investigate the parameters related to disease activity in patients with Ankylosing Spondylitis (AS). Materials and methods: Fifty-three patients with AS who fulfilled the modified New York criteria were included in this study. The demographic data of the patients were recorded. Laboratory evaluation of the patients comprised erythrocyte sedimentat...

The pathogenesis of the cauda equina syndrome of ankylosing spondylitis is unknown. The long duration between the onset of ankylosing spondylitis and neurological symptoms (average 35 years in the Mayo Clinic series') argues against a shared inflammatory cause, as does the relative normality of CSF.' 2 Matthews suggested that arterial pulsations transmitted to the CSF might produce not only the...

Anti-tumor necrosis factor agents are effective drugs for inflammatory diseases such as rheumatoid arthritis and bowel disease. Although it is indicated the treatment of Ankylosing Spondylitis, there recent publications about paradoxical side effects due to these agents, mostly in form case reports. In this article, we present psoriasis that develops paradoxically a patient with ankylosing spon...

Ankylosing spinal disorders (ASD) tend to result in fractures and/or dislocations after minor trauma because of the altered biomechanical properties. The relative risk of traumatic vertebral fractures in patients with ankylosing spondylitis has been estimated as three times higher than in the general population. These spine traumas, which are located at cervical level in 81% of patients with an...

The occurrence of heart disease in rheumatoid arthritis and ankylosing spondylitis has been known for a considerable time, but its exact incidence and status has been the subject of much controversy, further confused by the North American inclusion of both diseases under one heading. In a survey of the subject in 1950, Bywaters distinguished three combinations: patients with rheumatoid arthriti...

There has been recent interest in the association between human leucocyte antigen-27 and ankylosing spondylitis. Brewerton, Caffrey, Hart, James, Nicholls, and Sturrock (1973) and Schlosstein, Terasaki, Bluestone, and Pearson (1973) demonstrated this antigen in 96% and 87% of ankylosing spondylitics, respectively, as compared with about 5%in normal controls. It is well known that recurrent Reit...

A review of the roentgen films and hospital charts in 100 examples of chronic ulcerative colitis showed a 6 per cent prevalence of ankylosing spondylitis. There were no differences in the course or severity of the colitis that distinguished the patients with spondylitis from the entire group. The radiologic features of the spinal involvement were identical to those seen in ankylosing spondyliti...

Bath medallion reproduced with permission of the Royal National Hospital for Rheumatic Diseases, Bath. The seronegative spondyloarthropathies consist ofa group ofdisorders which includes idiopathic (primary) ankylosing spondylitis, juvenile ankylosing spondylitis, reactive arthritis (or Reiter's syndrome), psoriatic arthritis, and spondylitis of inflammatory bowel disease (enteropathic spondylo...