Ultrastructural alterations of columnar respiratory epithe lium were produced by certain polycyclic aromatic hydrocar bons in suckling rat trachea maintained in organ culture for 11 days. The potent carcinogens 7,12-dimethylbenz(a)anthracene (DMBA) and benzo(a)pyrene and the weakly carci nogenic compounds benz(a)anthracene and 5-fluoro-7,12-dimethylbenz(a)anthracene (F-DMBA) produced cells whos...

The degradation of 7,12-dimethylbenz[a]anthracene (DMBA), a carcinogenic polycyclic aromatic hydrocarbon, by cultures of Mycobacterium vanbaalenii PYR-1 was studied. When M. vanbaalenii PYR-1 was grown in the presence of DMBA for 136 h, high-pressure liquid chromatography (HPLC) analysis showed the presence of four ethyl acetate-extractable compounds and unutilized substrate. Characterization o...

Benzo(a)anthracene (BA) and several benzo-ring deriv atives of BA were tested for their tumor-initiating activity on mouse skin. A single topical application of 0.1 to 2.0 /<mol of hydrocarbon was followed 7 days later by twiceweekly applications of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate for 20 weeks. Comparisons of the percentage of mice with papillomas and the number of papil...

Two photoactive cyclodextrin hosts have been prepared and studied in participation on photophysical processes, one with a ruthenium tris(bipyridyl) core which forms a trimeric host and the other with an appended anthracene unit. An acetylide functionalized bipyridyl cyclodextrin, , was prepared by palladium coupling of mono-6-propargyl permethylated beta-CD and 4-bromo-2,2'-bipyridine. The ruth...

1. Unsubstituted 6-membered aromatic ring systems (fused, unfused, or mixed) chrysene mutagenic initiator carcinogenic pyrene co-carcinogen mutagenic benzo[a]pyrene mutagenic carcinogenic fetotoxic teratogenic benzo[e]pyrene carcinogenic mutagenic benzo[a]anthracene mutagenic carcinogenic benzo[c]phenanthrene initiator mutagenic naphthalene inhibitor phenanthrene initiator mutagenic anthracene ...

Reaction of tetrafluoropyridazine with catechol gives a tricyclic 9,10-dioxa-1,2-diaza-anthracene system by a sequential nucleophilic aromatic substitution ring annelation process, further extending the use of perfluoroheteroaromatic derivatives for the synthesis of unusual polyfunctional heterocyclic architectures. The tricyclic scaffold reacts with amines and sodium ethoxide providing a short...

N-Cinnamoyl-9-aminoanthracenes cyclise with PPA or triflic acid to form novel 2-azahexacyclo[10.6.6.0(1,5).0(6,11).0(13,18).0(19,24)]tetracosa-6(11),7,9,13,15,17,19(24),20,22-nonaen-3-ones. In contrast, both N-cinnamoyl-N-methyl-9-(2-aminomethyl)anthracene and N-cinnamoyl-9-(2-aminoethyl)anthracene undergo an intramolecular Diels-Alder cycloaddition.

7,12-DimethyIbenz(a)anthracene, a carcinogenic polycyclic aromatic hydrocarbon compound, significantly en hanced the transplantability and stimulated the growth of a pituitary tumor in rats. Estrogen was less effective than 7,12-dimethylbenz(a)anthracne. The combination of 7,12dimethylbenz(a)anthracene and estrogen showed a synergistic effect. Hormone production by the tumor was not impaired by...

An anthracene derivative, 2,6-diphenyl anthracene (DPA), was successfully synthesized with three simple steps and a high yield. The compound was determined to be a durable high performing semiconductor with thin film device mobility over 10 cm(2) V(-1) s(-1). The efficient synthesis and high performance indicates its great potential in organic electronics.