Curcumin, is a polyphenol from Curcuma longa (turmeric plant), is a polyphenol that belongs to the ginger family which has long been used in Ayurveda medicines to treat various diseases such as asthma, anorexia, coughing, hepatic diseases, diabetes, heart diseases, wound healing and Alzheimer's. Various studies have shown that curcumin has anti-infectious, anti-inflammatory, anti-oxidant, hepat...

The European Food Safety Authority has prepared a draft for a harmonised strategy for the risk assessment of genotoxic and carcinogenic substances and presented this draft for discussion. The concept examines the exposure of the consumer to a specific substance and compares this with the carcinogenic effect of a defined dose in an animal experiment. Genotoxic and carcinogenic compounds are thus...

Acute myeloid leukemia (AML) is a hematological malignancy with a low survival rate. Curcumin, which is a multi-targeted anticancer agent, has been shown to exert anti‐oxidant, anti‐inflammatory, anti‐mutagenic and anti-carcinogenic activities. Naringenin is extracted from citrus fruits and exerts anti-mutagenic and anti-carcinogenic activities in various types of cancer cells. However, the eff...

objective(s):sea cucumber is one of the classes of echinoderms, which is considered as a health marine product and possess various biological characteristics with therapeutic application. the present investigation attempted to evaluate the potential of anti-cancer persian gulf sea cucumber species holothuria arenicola (h. arenicola) aqueous extract on mice colon carcinoma cells in vitro and in ...

cuminum cyminum linn. (umbelliferae) is a plant, which has been used as a toothache remedy in folk medicine of iran. in this study, the potential anti-nociceptive and anti-inflammatory activities of the fruit essential oil of c. cyminum has been evaluated in chemical (formalin test) and thermal (tail-flick test) models of nociception and formalin model of acute inflammation in rats and mice. th...

The objective of this paper was to study the extraction methods of tannin constituents from Semen Cuscutae and their anti-papilloma effects. Single factor test and orthogonal design methods were used to determine the optimal extraction method; the mouse skin papilloma model induced by DMBA/croton oil was established, which was a classic two-stage carcinogenesis model being used to observe and e...

background: radon and its short-lived decay products are considered as the important sources of public exposure to natural radioactivity. the synergistic interaction between tobacco smoking and radon is known to be an actual problem. this study has provided a mathematical description and prognosis of the carcinogenic effects after combined action of radon with smoking. materials and methods: a ...

Bioassays for carcinogenicity of various primary processing products (crude oils or tars) and commercial products obtained from Estorian oil shale have been carried out since 1951. The products (undiluted or diluted) were painted twice weekly 50 times on the interscapular area of the skin of random-bred or CC57Br mice. The products processed at high temperatures have a higher carcinogenic activ...